Microtubule-associated protein tau

Intermolecular

A redox-regulated disulphide may form between two units of Microtubule-associated protein tau at cysteines 639 and 608 (322 and 291 respectively in this structure).

Details

Redox score ?

PDB code

7ql2

Structure name

in vitro assembled 244-391 tau filaments with na2p2o7 (20a)

Structure deposition date

2021-12-19

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Microtubule-associated protein tau

Peptide B name

Microtubule-associated protein tau

Peptide A accession

P10636

Peptide B accession

P10636

Peptide A residue number

639

Peptide B residue number

608

Ligandability

Cysteine 639 of Microtubule-associated protein tau

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Microtubule-associated protein tau

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Microtubule-associated protein tau at cysteines 608 and 608 (291 and 291 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7qkh

Structure name

in vitro assembled 258-391 tau filaments with sodium azide, (41a)

Structure deposition date

2021-12-17

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

Microtubule-associated protein tau

Peptide B name

Microtubule-associated protein tau

Peptide A accession

P10636

Peptide B accession

P10636

Peptide A residue number

608

Peptide B residue number

608

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Isoform Tau-F of Microtubule-associated protein tau at cysteines 322 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?