ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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cAMP-dependent protein kinase type I-alpha regulatory subunit

Intermolecular
Cysteine 38 and cysteine 17 L
A redox-regulated disulphide is known to form between two units of cAMP-dependent protein kinase type I-alpha regulatory subunit at cysteines 38 and 17 (37 and 16 respectively in this structure).

Details

Redox score ?
85
PDB code
3im4
Structure name
crystal structure of camp-dependent protein kinase a regulatory subunit i alpha in complex with dual-specific a- kinase anchoring protein 2
Structure deposition date
2009-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide A name
cAMP-dependent protein kinase type I-alpha regulatory subunit
Peptide B name
cAMP-dependent protein kinase type I-alpha regulatory subunit
Peptide A accession
P00514
Peptide B accession
P00514
Peptide A residue number
38
Peptide B residue number
17

Ligandability

Cysteine 38 of cAMP-dependent protein kinase type I-alpha regulatory subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 17 of cAMP-dependent protein kinase type I-alpha regulatory subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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