ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mast/stem cell growth factor receptor Kit

Intermolecular
Cysteine 674 and cysteine 674
Intramolecular
Cysteine 443 and cysteine 450
Cysteine 151 and cysteine 183
Cysteine 58 and cysteine 97
Cysteine 233 and cysteine 290
Cysteine 136 and cysteine 186
Cysteine 428 and cysteine 491
Cysteine 673 and cysteine 674
Cysteine 673 and cysteine 809
A redox-regulated disulphide may form between two units of Mast/stem cell growth factor receptor Kit at cysteines 674 and 674.

Details

Redox score ?
77
PDB code
6xv9
Structure name
crystal structure of the kinase domain of human c-kit in complex with a type-ii inhibitor
Structure deposition date
2020-01-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
4
% buried
100
Peptide A name
Mast/stem cell growth factor receptor Kit
Peptide B name
Mast/stem cell growth factor receptor Kit
Peptide A accession
P10721
Peptide B accession
P10721
Peptide A residue number
674
Peptide B residue number
674

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 443 and 450.

Details

Redox score ?
87
PDB code
4pgz
Structure name
structural basis of kit activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand- dependent or oncogenic receptor tyrosine kinase activation
Structure deposition date
2014-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10721
Residue number A
443
Residue number B
450
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 443 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 450 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 151 and 183.

Details

Redox score ?
84
PDB code
2e9w
Structure name
crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
Structure deposition date
2007-01-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10721
Residue number A
151
Residue number B
183
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 151 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 58 and 97.

Details

Redox score ?
83
PDB code
2e9w
Structure name
crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
Structure deposition date
2007-01-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10721
Residue number A
58
Residue number B
97
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 58 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 233 and 290.

Details

Redox score ?
82
PDB code
2e9w
Structure name
crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
Structure deposition date
2007-01-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10721
Residue number A
233
Residue number B
290
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 233 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 290 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 136 and 186.

Details

Redox score ?
81
PDB code
2e9w
Structure name
crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
Structure deposition date
2007-01-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10721
Residue number A
136
Residue number B
186
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 136 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 428 and 491.

Details

Redox score ?
80
PDB code
2e9w
Structure name
crystal structure of the extracellular domain of kit in complex with stem cell factor (scf)
Structure deposition date
2007-01-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10721
Residue number A
428
Residue number B
491
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 428 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 491 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 673 and 674. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3g0f
Structure name
kit kinase domain mutant d816h in complex with sunitinib
Structure deposition date
2009-01-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
48
Peptide accession
P10721
Residue number A
673
Residue number B
674
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 673 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 674 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mast/stem cell growth factor receptor Kit between cysteines 673 and 809. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6gqj
Structure name
crystal structure of human c-kit kinase domain in complex with azd3229-analogue (compound 18)
Structure deposition date
2018-06-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
14
% buried
100
Peptide accession
P10721
Residue number A
673
Residue number B
809
Peptide name
Mast/stem cell growth factor receptor Kit

Ligandability

Cysteine 673 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 809 of Mast/stem cell growth factor receptor Kit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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