ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell-specific surface glycoprotein CD28

Intramolecular
Cysteine 66 and cysteine 86
Cysteine 40 and cysteine 112
A redox-regulated disulphide may form within T-cell-specific surface glycoprotein CD28 between cysteines 66 and 86.

Details

Redox score ?
85
PDB code
6o8d
Structure name
anti-cd28xcd3 codv fab bound to cd28
Structure deposition date
2019-03-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10747
Residue number A
66
Residue number B
86
Peptide name
T-cell-specific surface glycoprotein CD28

Ligandability

Cysteine 66 of T-cell-specific surface glycoprotein CD28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 86 of T-cell-specific surface glycoprotein CD28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell-specific surface glycoprotein CD28 between cysteines 40 and 112.

Details

Redox score ?
81
PDB code
6o8d
Structure name
anti-cd28xcd3 codv fab bound to cd28
Structure deposition date
2019-03-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10747
Residue number A
40
Residue number B
112
Peptide name
T-cell-specific surface glycoprotein CD28

Ligandability

Cysteine 40 of T-cell-specific surface glycoprotein CD28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of T-cell-specific surface glycoprotein CD28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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