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a tool for identifying drug-targetable redox-active disulphides

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Retinoic acid receptor beta

Intramolecular
Cysteine 130 and cysteine 140
Cysteine 88 and cysteine 108
Cysteine 130 and cysteine 143
Cysteine 124 and cysteine 143
Cysteine 91 and cysteine 108
Cysteine 105 and cysteine 108
Cysteine 124 and cysteine 140
Cysteine 124 and cysteine 130
Cysteine 108 and cysteine 148
Cysteine 140 and cysteine 143
More...
Cysteine 88 and cysteine 91
Cysteine 91 and cysteine 105
Cysteine 91 and cysteine 130
Cysteine 88 and cysteine 143
Cysteine 88 and cysteine 148
Cysteine 88 and cysteine 105
Cysteine 91 and cysteine 140
Cysteine 333 and cysteine 336
Cysteine 91 and cysteine 143
Cysteine 130 and cysteine 148
Cysteine 143 and cysteine 148
Cysteine 91 and cysteine 148
Cysteine 105 and cysteine 148
Cysteine 262 and cysteine 292
Cysteine 108 and cysteine 143
Cysteine 265 and cysteine 333
A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 130 and 140 (123 and 133 respectively in this structure).

Details

Redox score ?
87
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
10
Peptide accession
P10826
Residue number A
130
Residue number B
140
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 130 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 140 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 88 and 108 (81 and 101 respectively in this structure).

Details

Redox score ?
85
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
4
% buried
nan
Peptide accession
P10826
Residue number A
88
Residue number B
108
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 88 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 130 and 143 (123 and 136 respectively in this structure).

Details

Redox score ?
85
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
51
Minimum pKa ?
7
% buried
9
Peptide accession
P10826
Residue number A
130
Residue number B
143
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 130 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 124 and 143 (117 and 136 respectively in this structure).

Details

Redox score ?
85
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
18
Peptide accession
P10826
Residue number A
124
Residue number B
143
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 124 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 91 and 108 (84 and 101 respectively in this structure).

Details

Redox score ?
84
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
4
% buried
75
Peptide accession
P10826
Residue number A
91
Residue number B
108
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 105 and 108 (98 and 101 respectively in this structure).

Details

Redox score ?
83
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
4
% buried
84
Peptide accession
P10826
Residue number A
105
Residue number B
108
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 105 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 124 and 140 (117 and 133 respectively in this structure).

Details

Redox score ?
83
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
19
Peptide accession
P10826
Residue number A
124
Residue number B
140
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 124 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 140 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 124 and 130 (117 and 123 respectively in this structure).

Details

Redox score ?
81
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
45
Minimum pKa ?
7
% buried
10
Peptide accession
P10826
Residue number A
124
Residue number B
130
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 124 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 108 and 148 (101 and 141 respectively in this structure).

Details

Redox score ?
73
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
4
% buried
94
Peptide accession
P10826
Residue number A
108
Residue number B
148
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 108 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 140 and 143 (133 and 136 respectively in this structure).

Details

Redox score ?
70
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
18
Peptide accession
P10826
Residue number A
140
Residue number B
143
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 140 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 88 and 91 (81 and 84 respectively in this structure).

Details

Redox score ?
67
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
13
% buried
nan
Peptide accession
P10826
Residue number A
88
Residue number B
91
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 88 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 91 and 105 (84 and 98 respectively in this structure).

Details

Redox score ?
65
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
13
% buried
68
Peptide accession
P10826
Residue number A
91
Residue number B
105
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 91 and 130 (11 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
32
Peptide accession
P10826
Residue number A
91
Residue number B
130
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 88 and 143 (8 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
1
% buried
52
Peptide accession
P10826
Residue number A
88
Residue number B
143
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 88 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 88 and 148 (81 and 141 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
nan
Peptide accession
P10826
Residue number A
88
Residue number B
148
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 88 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 88 and 105 (81 and 98 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
22
% buried
nan
Peptide accession
P10826
Residue number A
88
Residue number B
105
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 88 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 91 and 140 (11 and 60 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
6
% buried
34
Peptide accession
P10826
Residue number A
91
Residue number B
140
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 140 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 333 and 336 (326 and 329 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
100
Peptide accession
P10826
Residue number A
333
Residue number B
336
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 333 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 91 and 143 (11 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
6
% buried
46
Peptide accession
P10826
Residue number A
91
Residue number B
143
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 130 and 148 (50 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
46
Peptide accession
P10826
Residue number A
130
Residue number B
148
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 130 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 143 and 148 (63 and 68 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
60
Peptide accession
P10826
Residue number A
143
Residue number B
148
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 91 and 148 (84 and 141 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
78
Peptide accession
P10826
Residue number A
91
Residue number B
148
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 91 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 105 and 148 (98 and 141 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5uan
Structure name
crystal structure of multi-domain rar-beta-rxr-alpha heterodimer on dna
Structure deposition date
2016-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
87
Peptide accession
P10826
Residue number A
105
Residue number B
148
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 105 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 262 and 292 (228 and 258 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1xdk
Structure name
crystal structure of the rarbeta/rxralpha ligand binding domain heterodimer in complex with 9-cis retinoic acid and a fragment of the trap220 coactivator
Structure deposition date
2004-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
100
Peptide accession
P22605
Residue number A
262
Residue number B
292
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 262 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 108 and 143 (28 and 63 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1hra
Structure name
the solution structure of the human retinoic acid receptor-beta dna- binding domain
Structure deposition date
1993-07-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
56
Peptide accession
P10826
Residue number A
108
Residue number B
143
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 108 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 143 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Retinoic acid receptor beta between cysteines 265 and 333 (258 and 326 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
6ssq
Structure name
crystal structure of rarbeta lbd in complex with lg 100754
Structure deposition date
2019-09-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
P10826
Residue number A
265
Residue number B
333
Peptide name
Retinoic acid receptor beta

Ligandability

Cysteine 265 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Retinoic acid receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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