Thyroid hormone receptor alpha

Intramolecular

A redox-regulated disulphide may form within Thyroid hormone receptor alpha between cysteines 254 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7qdt

Structure name

crystal structure of a mutant (p393gx) thyroid receptor alpha ligand binding domain designed to model dominant negative human mutations

Structure deposition date

2021-11-30

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P10827

Residue number A

254

Residue number B

255

Peptide name

Thyroid hormone receptor alpha

Ligandability

Cysteine 254 of Thyroid hormone receptor alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.