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a tool for identifying drug-targetable redox-active disulphides

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Thyroid hormone receptor beta

Intramolecular
Cysteine 145 and cysteine 161
Cysteine 151 and cysteine 161
Cysteine 145 and cysteine 151
Cysteine 107 and cysteine 110
Cysteine 161 and cysteine 164
Cysteine 145 and cysteine 164
Cysteine 151 and cysteine 164
Cysteine 110 and cysteine 124
Cysteine 110 and cysteine 127
Cysteine 107 and cysteine 124
More...
Cysteine 124 and cysteine 127
Cysteine 127 and cysteine 169
Cysteine 308 and cysteine 309
Cysteine 110 and cysteine 169
Cysteine 107 and cysteine 169
Cysteine 107 and cysteine 127
Cysteine 121 and cysteine 169
Cysteine 107 and cysteine 121
Cysteine 294 and cysteine 298
Cysteine 124 and cysteine 169
A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 145 and 161 (144 and 160 respectively in this structure).

Details

Redox score ?
88
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
7
Peptide accession
P18113
Residue number A
145
Residue number B
161
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 145 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 151 and 161 (347 and 357 respectively in this structure).

Details

Redox score ?
87
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
4
Peptide accession
P10828
Residue number A
151
Residue number B
161
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 151 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 145 and 151 (341 and 347 respectively in this structure).

Details

Redox score ?
87
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
P10828
Residue number A
145
Residue number B
151
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 145 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 107 and 110 (303 and 306 respectively in this structure).

Details

Redox score ?
86
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
4
% buried
nan
Peptide accession
P10828
Residue number A
107
Residue number B
110
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 107 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 161 and 164 (357 and 360 respectively in this structure).

Details

Redox score ?
84
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
6
Peptide accession
P10828
Residue number A
161
Residue number B
164
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 161 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 145 and 164 (341 and 360 respectively in this structure).

Details

Redox score ?
82
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
8
% buried
2
Peptide accession
P10828
Residue number A
145
Residue number B
164
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 145 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 151 and 164 (347 and 360 respectively in this structure).

Details

Redox score ?
80
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
2
Peptide accession
P10828
Residue number A
151
Residue number B
164
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 151 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 110 and 124 (109 and 123 respectively in this structure).

Details

Redox score ?
79
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
64
Peptide accession
P18113
Residue number A
110
Residue number B
124
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 110 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 110 and 127 (109 and 126 respectively in this structure).

Details

Redox score ?
78
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
6
% buried
68
Peptide accession
P18113
Residue number A
110
Residue number B
127
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 110 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 107 and 124 (303 and 320 respectively in this structure).

Details

Redox score ?
67
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
14
% buried
nan
Peptide accession
P10828
Residue number A
107
Residue number B
124
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 107 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 124 and 127 (123 and 126 respectively in this structure).

Details

Redox score ?
62
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
15
% buried
80
Peptide accession
P18113
Residue number A
124
Residue number B
127
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 124 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 127 and 169 (126 and 168 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
92
Peptide accession
P18113
Residue number A
127
Residue number B
169
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 127 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 308 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6kkb
Structure name
a novel agonist of thrb
Structure deposition date
2019-07-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
P10828
Residue number A
308
Residue number B
309
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 308 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 110 and 169 (109 and 168 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
6
% buried
76
Peptide accession
P18113
Residue number A
110
Residue number B
169
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 110 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 107 and 169 (303 and 365 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
nan
Peptide accession
P10828
Residue number A
107
Residue number B
169
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 107 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 107 and 127 (303 and 323 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
23
% buried
nan
Peptide accession
P10828
Residue number A
107
Residue number B
127
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 107 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 121 and 169 (120 and 168 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
66
Peptide accession
P18113
Residue number A
121
Residue number B
169
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 121 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 107 and 121 (303 and 317 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2nll
Structure name
retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna
Structure deposition date
1996-11-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
nan
Peptide accession
P10828
Residue number A
107
Residue number B
121
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 107 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 294 and 298. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1r6g
Structure name
crystal structure of the thyroid hormone receptor beta ligand binding domain in complex with a beta selective compound
Structure deposition date
2003-10-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
39
Minimum pKa ?
9
% buried
4
Peptide accession
P10828
Residue number A
294
Residue number B
298
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 294 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 298 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroid hormone receptor beta between cysteines 124 and 169 (123 and 168 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3m9e
Structure name
thyroid hormone beta dna binding domain homodimer with inverted palindrome tre
Structure deposition date
2010-03-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
12
% buried
88
Peptide accession
P18113
Residue number A
124
Residue number B
169
Peptide name
Thyroid hormone receptor beta

Ligandability

Cysteine 124 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Thyroid hormone receptor beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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