ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Heat shock cognate 71 kDa protein

Intermolecular
Cysteine 603 and cysteine 574
Intramolecular
Cysteine 574 and cysteine 603
A redox-regulated disulphide may form between two units of Heat shock cognate 71 kDa protein at cysteines 603 and 574.

Details

Redox score ?
65
PDB code
1ud0
Structure name
crystal structure of the c-terminal 10-kda subdomain of hsc70
Structure deposition date
2003-04-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
56
Peptide A name
Heat shock cognate 71 kDa protein
Peptide B name
Heat shock cognate 71 kDa protein
Peptide A accession
P63018
Peptide B accession
P63018
Peptide A residue number
603
Peptide B residue number
574

Ligandability

Cysteine 603 of Heat shock cognate 71 kDa protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 574 of Heat shock cognate 71 kDa protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Heat shock cognate 71 kDa protein between cysteines 574 and 603.

Details

Redox score ?
76
PDB code
4kbq
Structure name
structure of the chip-tpr domain in complex with the hsc70 lid-tail domains
Structure deposition date
2013-04-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
51
Peptide accession
P11142
Residue number A
574
Residue number B
603
Peptide name
Heat shock cognate 71 kDa protein

Ligandability

Cysteine 574 of Heat shock cognate 71 kDa protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 603 of Heat shock cognate 71 kDa protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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