a tool for identifying drug-targetable redox-active disulphides

Solute carrier family 2, facilitated glucose transporter member 3

Intramolecular

Cysteine 131 and cysteine 134

A redox-regulated disulphide may form within Solute carrier family 2, facilitated glucose transporter member 3 between cysteines 131 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

crystal structure of human glucose transporter glut3 bound with exofacial inhibitor sa47

Structure deposition date

2021-11-03

Thiol separation (Å)

6

Half-sphere exposure sum ?

108

Minimum pK_a ?

13

% buried

100

Peptide accession

Residue number A

131

Residue number B

134

Peptide name

Solute carrier family 2, facilitated glucose transporter member 3

Ligandability

Cysteine 131 of Solute carrier family 2, facilitated glucose transporter member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Solute carrier family 2, facilitated glucose transporter member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: