Uridine 5'-monophosphate synthase
Intramolecular
Cysteine 72 and cysteine 119
Cysteine 255 and cysteine 278
Cysteine 72 and cysteine 86
Cysteine 86 and cysteine 119
2wns B 72 B 119
A redox-regulated disulphide may form within Uridine 5'-monophosphate synthase between cysteines 72 and 119.
Details
Redox score ?
64
PDB code
2wns
Structure name
human orotate phosphoribosyltransferase (oprtase) domain of uridine 5'-monophosphate synthase (umps) in complex with its substrate orotidine 5'-monophosphate (omp)
Structure deposition date
2009-07-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
91
Minimum pKa ?
8
% buried
100
Peptide accession
P11172
Residue number A
72
Residue number B
119
Peptide name
Uridine 5'-monophosphate synthase
Ligandability
Cysteine 72 of Uridine 5'-monophosphate synthase
Cysteine 119 of Uridine 5'-monophosphate synthase
3ex6 B 255 B 278
A redox-regulated disulphide may form within Uridine 5'-monophosphate synthase between cysteines 255 and 278. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3ex6
Structure name
d312n mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-ump, covalent adduct
Structure deposition date
2008-10-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
P11172
Residue number A
255
Residue number B
278
Peptide name
Uridine 5'-monophosphate synthase
Ligandability
Cysteine 255 of Uridine 5'-monophosphate synthase
Cysteine 278 of Uridine 5'-monophosphate synthase
2wns B 72 B 86
A redox-regulated disulphide may form within Uridine 5'-monophosphate synthase between cysteines 72 and 86. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
2wns
Structure name
human orotate phosphoribosyltransferase (oprtase) domain of uridine 5'-monophosphate synthase (umps) in complex with its substrate orotidine 5'-monophosphate (omp)
Structure deposition date
2009-07-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
8
% buried
100
Peptide accession
P11172
Residue number A
72
Residue number B
86
Peptide name
Uridine 5'-monophosphate synthase
Ligandability
Cysteine 72 of Uridine 5'-monophosphate synthase
Cysteine 86 of Uridine 5'-monophosphate synthase
2wns A 86 A 119
A redox-regulated disulphide may form within Uridine 5'-monophosphate synthase between cysteines 86 and 119. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
2wns
Structure name
human orotate phosphoribosyltransferase (oprtase) domain of uridine 5'-monophosphate synthase (umps) in complex with its substrate orotidine 5'-monophosphate (omp)
Structure deposition date
2009-07-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide accession
P11172
Residue number A
86
Residue number B
119
Peptide name
Uridine 5'-monophosphate synthase
Ligandability
Cysteine 86 of Uridine 5'-monophosphate synthase
Cysteine 119 of Uridine 5'-monophosphate synthase
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