ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Integrin alpha-M

Intramolecular
Cysteine 113 and cysteine 144
Cysteine 998 and cysteine 1032
Cysteine 847 and cysteine 864
Cysteine 654 and cysteine 711
Cysteine 1022 and cysteine 1027
Cysteine 494 and cysteine 505
Cysteine 770 and cysteine 776
Cysteine 638 and cysteine 721
Cysteine 66 and cysteine 73
Cysteine 105 and cysteine 123
More...
Cysteine 144 and cysteine 318
Cysteine 132 and cysteine 315
A redox-regulated disulphide may form within Integrin alpha-M between cysteines 113 and 144 (97 and 128 respectively in this structure).

Details

Redox score ?
86
PDB code
7p2d
Structure name
structure of alphambeta2/cd11bcd18 headpiece in complex with a nanobody
Structure deposition date
2021-07-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11215
Residue number A
113
Residue number B
144
Peptide name
Integrin alpha-M

Ligandability

Cysteine 113 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 998 and 1032 (982 and 1016 respectively in this structure).

Details

Redox score ?
86
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11215
Residue number A
998
Residue number B
1032
Peptide name
Integrin alpha-M

Ligandability

Cysteine 998 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1032 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 847 and 864 (831 and 848 respectively in this structure).

Details

Redox score ?
84
PDB code
7usl
Structure name
integrin alpham/beta2 ectodomain in complex with adenylate cyclase toxin rtx751 and m1f5 fab
Structure deposition date
2022-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11215
Residue number A
847
Residue number B
864
Peptide name
Integrin alpha-M

Ligandability

Cysteine 847 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 864 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 654 and 711 (638 and 695 respectively in this structure).

Details

Redox score ?
83
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
6
Peptide accession
P11215
Residue number A
654
Residue number B
711
Peptide name
Integrin alpha-M

Ligandability

Cysteine 654 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 711 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 1022 and 1027 (1006 and 1011 respectively in this structure).

Details

Redox score ?
81
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11215
Residue number A
1022
Residue number B
1027
Peptide name
Integrin alpha-M

Ligandability

Cysteine 1022 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1027 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 494 and 505 (478 and 489 respectively in this structure).

Details

Redox score ?
81
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
66
Peptide accession
P11215
Residue number A
494
Residue number B
505
Peptide name
Integrin alpha-M

Ligandability

Cysteine 494 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 505 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 770 and 776 (754 and 760 respectively in this structure).

Details

Redox score ?
80
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
10
% buried
30
Peptide accession
P11215
Residue number A
770
Residue number B
776
Peptide name
Integrin alpha-M

Ligandability

Cysteine 770 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 776 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 638 and 721 (622 and 705 respectively in this structure).

Details

Redox score ?
80
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
P11215
Residue number A
638
Residue number B
721
Peptide name
Integrin alpha-M

Ligandability

Cysteine 638 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 721 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 66 and 73 (50 and 57 respectively in this structure).

Details

Redox score ?
75
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
62
Peptide accession
P11215
Residue number A
66
Residue number B
73
Peptide name
Integrin alpha-M

Ligandability

Cysteine 66 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 73 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 105 and 123 (89 and 107 respectively in this structure).

Details

Redox score ?
69
PDB code
7usm
Structure name
integrin alpham/beta2 ectodomain
Structure deposition date
2022-04-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
93
Minimum pKa ?
9
% buried
96
Peptide accession
P11215
Residue number A
105
Residue number B
123
Peptide name
Integrin alpha-M

Ligandability

Cysteine 105 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Integrin alpha-M between cysteines 144 and 318 (128 and 318 respectively in this structure).

Details

Redox score ?
nan
PDB code
1mf7
Structure name
integrin alpha m i domain
Structure deposition date
2002-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11215
Residue number A
144
Residue number B
318
Peptide name
Integrin alpha-M

Ligandability

Cysteine 144 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Integrin alpha-M between cysteines 132 and 315.

Details

Redox score ?
nan
PDB code
1n9z
Structure name
integrin alpha m i domain mutant
Structure deposition date
2002-11-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
P11215
Residue number A
132
Residue number B
315
Peptide name
Integrin alpha-M

Ligandability

Cysteine 132 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Integrin alpha-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 in protein A could not be asigned to a Uniprot residue.
Cysteine 315 in protein B could not be asigned to a Uniprot residue.
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