a tool for identifying drug-targetable redox-active disulphides

Glycogen phosphorylase, brain form

Intramolecular

Cysteine 373 and cysteine 446

A redox-regulated disulphide may form within Glycogen phosphorylase, brain form between cysteines 373 and 446 (372 and 445 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

32

PDB code

Structure name

crystal structure of human brain glycogen phosphorylase bound to amp

Structure deposition date

2016-03-03

Thiol separation (Å)

9

Half-sphere exposure sum ?

90

Minimum pK_a ?

12

% buried

100

Peptide accession

Residue number A

373

Residue number B

446

Peptide name

Glycogen phosphorylase, brain form

Ligandability

Cysteine 373 of Glycogen phosphorylase, brain form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of Glycogen phosphorylase, brain form

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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