ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mannose-binding protein C

Intramolecular
Cysteine 155 and cysteine 244
Cysteine 222 and cysteine 236
A redox-regulated disulphide may form within Mannose-binding protein C between cysteines 155 and 244 (135 and 224 respectively in this structure).

Details

Redox score ?
82
PDB code
1hup
Structure name
human mannose binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil
Structure deposition date
1994-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11226
Residue number A
155
Residue number B
244
Peptide name
Mannose-binding protein C

Ligandability

Cysteine 155 of Mannose-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Mannose-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mannose-binding protein C between cysteines 222 and 236 (202 and 216 respectively in this structure).

Details

Redox score ?
81
PDB code
1hup
Structure name
human mannose binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil
Structure deposition date
1994-09-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11226
Residue number A
222
Residue number B
236
Peptide name
Mannose-binding protein C

Ligandability

Cysteine 222 of Mannose-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of Mannose-binding protein C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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