ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Muscarinic acetylcholine receptor M1

Intramolecular
Cysteine 391 and cysteine 394
Cysteine 98 and cysteine 178
Cysteine 417 and cysteine 421
A redox-regulated disulphide may form within Muscarinic acetylcholine receptor M1 between cysteines 391 and 394.

Details

Redox score ?
85
PDB code
6wjc
Structure name
muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex
Structure deposition date
2020-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11229
Residue number A
391
Residue number B
394
Peptide name
Muscarinic acetylcholine receptor M1

Ligandability

Cysteine 391 of Muscarinic acetylcholine receptor M1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 394 of Muscarinic acetylcholine receptor M1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Muscarinic acetylcholine receptor M1 between cysteines 98 and 178.

Details

Redox score ?
77
PDB code
6oij
Structure name
muscarinic acetylcholine receptor 1-g11 protein complex
Structure deposition date
2019-04-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
7
% buried
50
Peptide accession
P11229
Residue number A
98
Residue number B
178
Peptide name
Muscarinic acetylcholine receptor M1

Ligandability

Cysteine 98 of Muscarinic acetylcholine receptor M1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Muscarinic acetylcholine receptor M1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Muscarinic acetylcholine receptor M1 between cysteines 417 and 421.

Details

Redox score ?
60
PDB code
6wjc
Structure name
muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex
Structure deposition date
2020-04-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
46
Peptide accession
P11229
Residue number A
417
Residue number B
421
Peptide name
Muscarinic acetylcholine receptor M1

Ligandability

Cysteine 417 of Muscarinic acetylcholine receptor M1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 421 of Muscarinic acetylcholine receptor M1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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