ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Arylamine N-acetyltransferase 2

Intramolecular
Cysteine 223 and cysteine 233
Cysteine 148 and cysteine 151
A redox-regulated disulphide may form within Arylamine N-acetyltransferase 2 between cysteines 223 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2pfr
Structure name
human n-acetyltransferase 2
Structure deposition date
2007-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11245
Residue number A
223
Residue number B
233
Peptide name
Arylamine N-acetyltransferase 2

Ligandability

Cysteine 223 of Arylamine N-acetyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of Arylamine N-acetyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Arylamine N-acetyltransferase 2 between cysteines 148 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2pfr
Structure name
human n-acetyltransferase 2
Structure deposition date
2007-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11245
Residue number A
148
Residue number B
151
Peptide name
Arylamine N-acetyltransferase 2

Ligandability

Cysteine 148 of Arylamine N-acetyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Arylamine N-acetyltransferase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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