ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysosome-associated membrane glycoprotein 1

Intramolecular
Cysteine 327 and cysteine 364
Cysteine 222 and cysteine 259
A redox-regulated disulphide may form within Lysosome-associated membrane glycoprotein 1 between cysteines 327 and 364.

Details

Redox score ?
87
PDB code
5gv0
Structure name
crystal structure of the membrane-proximal domain of mouse lysosome- associated membrane protein 1 (lamp-1)
Structure deposition date
2016-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11438
Residue number A
327
Residue number B
364
Peptide name
Lysosome-associated membrane glycoprotein 1

Ligandability

Cysteine 327 of Lysosome-associated membrane glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Lysosome-associated membrane glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosome-associated membrane glycoprotein 1 between cysteines 222 and 259.

Details

Redox score ?
83
PDB code
5gv0
Structure name
crystal structure of the membrane-proximal domain of mouse lysosome- associated membrane protein 1 (lamp-1)
Structure deposition date
2016-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11438
Residue number A
222
Residue number B
259
Peptide name
Lysosome-associated membrane glycoprotein 1

Ligandability

Cysteine 222 of Lysosome-associated membrane glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Lysosome-associated membrane glycoprotein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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