ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Intramolecular
Cysteine 116 and cysteine 244
Cysteine 156 and cysteine 159
A redox-regulated disulphide may form within Medium-chain specific acyl-CoA dehydrogenase, mitochondrial between cysteines 116 and 244 (91 and 219 respectively in this structure).

Details

Redox score ?
69
PDB code
1ege
Structure name
structure of t255e, e376g mutant of human medium chain acyl- coa dehydrogenase
Structure deposition date
1996-04-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
6
% buried
98
Peptide accession
P11310
Residue number A
116
Residue number B
244
Peptide name
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Ligandability

Cysteine 116 of Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 244 of Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Medium-chain specific acyl-CoA dehydrogenase, mitochondrial between cysteines 156 and 159 (131 and 134 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
1ege
Structure name
structure of t255e, e376g mutant of human medium chain acyl- coa dehydrogenase
Structure deposition date
1996-04-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
100
Peptide accession
P11310
Residue number A
156
Residue number B
159
Peptide name
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Ligandability

Cysteine 156 of Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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