ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fibroblast growth factor receptor 1

Intramolecular
Cysteine 55 and cysteine 101
Cysteine 277 and cysteine 341
Cysteine 178 and cysteine 230
A redox-regulated disulphide may form within Fibroblast growth factor receptor 1 between cysteines 55 and 101 (25 and 71 respectively in this structure).

Details

Redox score ?
84
PDB code
2cr3
Structure name
solution structure of the first ig-like domain of human fibroblast growth factor receptor 1
Structure deposition date
2005-05-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11362
Residue number A
55
Residue number B
101
Peptide name
Fibroblast growth factor receptor 1

Ligandability

Cysteine 55 of Fibroblast growth factor receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Fibroblast growth factor receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor 1 between cysteines 277 and 341.

Details

Redox score ?
81
PDB code
1evt
Structure name
crystal structure of fgf1 in complex with the extracellular ligand binding domain of fgf receptor 1 (fgfr1)
Structure deposition date
2000-04-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11362
Residue number A
277
Residue number B
341
Peptide name
Fibroblast growth factor receptor 1

Ligandability

Cysteine 277 of Fibroblast growth factor receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 341 of Fibroblast growth factor receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fibroblast growth factor receptor 1 between cysteines 178 and 230.

Details

Redox score ?
80
PDB code
5w21
Structure name
crystal structure of a 1:1:1 fgf23-fgfr1c-aklotho ternary complex
Structure deposition date
2017-06-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11362
Residue number A
178
Residue number B
230
Peptide name
Fibroblast growth factor receptor 1

Ligandability

Cysteine 178 of Fibroblast growth factor receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Fibroblast growth factor receptor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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