a tool for identifying drug-targetable redox-active disulphides

DNA topoisomerase 1

Intramolecular

Cysteine 504 and cysteine 505 L

A redox-regulated disulphide may form within DNA topoisomerase 1 between cysteines 504 and 505.

Details

Redox score ?

64

PDB code

Structure name

human dna topoisomerase i (70 kda) in complex with the indolocarbazole sa315f and covalent complex with a 22 base pair dna duplex

Structure deposition date

2004-02-18

Thiol separation (Å)

4

Half-sphere exposure sum ?

81

Minimum pK_a ?

9

% buried

98

Peptide accession

Residue number A

504

Residue number B

505

Peptide name

DNA topoisomerase 1

Ligandability

Cysteine 504 of DNA topoisomerase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 505 of DNA topoisomerase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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