DNA topoisomerase 2-alpha

Intramolecular

A redox-regulated disulphide may form within DNA topoisomerase 2-alpha between cysteines 862 and 997. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

5gwk

Structure name

human topoisomerase iialpha in complex with dna and etoposide

Structure deposition date

2016-09-12

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P11388

Residue number A

862

Residue number B

997

Peptide name

DNA topoisomerase 2-alpha

Ligandability

Cysteine 862 of DNA topoisomerase 2-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.