ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Glucose-6-phosphate 1-dehydrogenase

Intramolecular
Cysteine 13 and cysteine 446 L
Cysteine 269 and cysteine 294
A redox-regulated disulphide may form within Glucose-6-phosphate 1-dehydrogenase between cysteines 13 and 446.

Details

Redox score ?
85
PDB code
1qki
Structure name
x-ray structure of human glucose 6-phosphate dehydrogenase (variant canton r459l) complexed with structural nadp+
Structure deposition date
1999-07-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11413
Residue number A
13
Residue number B
446
Peptide name
Glucose-6-phosphate 1-dehydrogenase

Ligandability

Cysteine 13 of Glucose-6-phosphate 1-dehydrogenase

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of Glucose-6-phosphate 1-dehydrogenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Glucose-6-phosphate 1-dehydrogenase between cysteines 269 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2bhl
Structure name
x-ray structure of human glucose-6-phosphate dehydrogenase (deletion variant) complexed with glucose-6-phosphate
Structure deposition date
2005-01-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
73
Peptide accession
P11413
Residue number A
269
Residue number B
294
Peptide name
Glucose-6-phosphate 1-dehydrogenase

Ligandability

Cysteine 269 of Glucose-6-phosphate 1-dehydrogenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of Glucose-6-phosphate 1-dehydrogenase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: