Pyruvate carboxylase, mitochondrial

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Pyruvate carboxylase, mitochondrial at cysteines 816 and 752. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3bg3

Structure name

crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus)

Structure deposition date

2007-11-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Pyruvate carboxylase, mitochondrial

Peptide B name

Pyruvate carboxylase, mitochondrial

Peptide A accession

P11498

Peptide B accession

P11498

Peptide A residue number

816

Peptide B residue number

752

Ligandability

Cysteine 816 of Pyruvate carboxylase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 752 of Pyruvate carboxylase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pyruvate carboxylase, mitochondrial between cysteines 752 and 786.

Details

Redox score ?

PDB code

3bg3

Structure name

crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus)

Structure deposition date

2007-11-26

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide accession

P11498

Residue number A

752

Residue number B

786

Peptide name

Pyruvate carboxylase, mitochondrial

Ligandability

Cysteine 752 of Pyruvate carboxylase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 786 of Pyruvate carboxylase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pyruvate carboxylase, mitochondrial between cysteines 265 and 376. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?