ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-1-tetrahydrofolate synthase, cytoplasmic

Intramolecular
Cysteine 152 and cysteine 236
Cysteine 147 and cysteine 152 L
A redox-regulated disulphide may form within C-1-tetrahydrofolate synthase, cytoplasmic between cysteines 152 and 236 (1152 and 1236 respectively in this structure).

Details

Redox score ?
67
PDB code
1dib
Structure name
human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly345899
Structure deposition date
1999-11-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
96
Minimum pKa ?
9
% buried
100
Peptide accession
P11586
Residue number A
152
Residue number B
236
Peptide name
C-1-tetrahydrofolate synthase, cytoplasmic

Ligandability

Cysteine 152 of C-1-tetrahydrofolate synthase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of C-1-tetrahydrofolate synthase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-1-tetrahydrofolate synthase, cytoplasmic between cysteines 147 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6ecp
Structure name
the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (fold) complexed with nadp and inhibitor ly249543
Structure deposition date
2018-08-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
P11586
Residue number A
147
Residue number B
152
Peptide name
C-1-tetrahydrofolate synthase, cytoplasmic

Ligandability

Cysteine 147 of C-1-tetrahydrofolate synthase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 152 of C-1-tetrahydrofolate synthase, cytoplasmic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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