ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Uteroglobin

Intermolecular
Cysteine 90 and cysteine 24
Cysteine 24 and cysteine 24
Intramolecular
Cysteine 100 and cysteine 90
Cysteine 24 and cysteine 90
A redox-regulated disulphide may form between two units of Uteroglobin at cysteines 90 and 24 (69 and 3 respectively in this structure).

Details

Redox score ?
87
PDB code
2utg
Structure name
structure and refinement of the oxidized p21 form of uteroglobin at 1
Structure deposition date
1989-05-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Uteroglobin
Peptide B name
Uteroglobin
Peptide A accession
P02779
Peptide B accession
P02779
Peptide A residue number
90
Peptide B residue number
24

Ligandability

Cysteine 90 of Uteroglobin

Cysteine 24 of Uteroglobin

A redox-regulated disulphide may form between two units of Uteroglobin at cysteines 24 and 24 (5 and 5 respectively in this structure).

Details

Redox score ?
60
PDB code
1utr
Structure name
uteroglobin-pcb complex (reduced form)
Structure deposition date
1995-09-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
32
Minimum pKa ?
9
% buried
0
Peptide A name
Uteroglobin
Peptide B name
Uteroglobin
Peptide A accession
P17559
Peptide B accession
P17559
Peptide A residue number
24
Peptide B residue number
24

Ligandability

A redox-regulated disulphide may form within Uteroglobin between cysteines 100 and 90 (100 and 114 respectively in this structure).

Details

Redox score ?
94
PDB code
7vf3
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m7 peptide
Structure deposition date
2021-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11684
Residue number A
100
Residue number B
90
Peptide name
Uteroglobin

Ligandability

Cysteine 100 of Uteroglobin

Cysteine 90 of Uteroglobin

Cysteine 100 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Uteroglobin between cysteines 24 and 90 (24 and 173 respectively in this structure).

Details

Redox score ?
91
PDB code
7vg7
Structure name
plexin b1 extracellular fragment in complex with lasso-grafted pb1m6a9 peptide
Structure deposition date
2021-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P11684
Residue number A
24
Residue number B
90
Peptide name
Uteroglobin

Ligandability

Cysteine 24 of Uteroglobin

Cysteine 90 of Uteroglobin

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