ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Proliferating cell nuclear antigen

Intermolecular
Cysteine 1011 of DNA polymerase delta catalytic subunit and cysteine 27 L
Intramolecular
Cysteine 135 and cysteine 162
A redox-regulated disulphide may form between cysteine 1011 of DNA polymerase delta catalytic subunit and cysteine 27 of Proliferating cell nuclear antigen. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6s1o
Structure name
human polymerase delta holoenzyme conformer 3
Structure deposition date
2019-06-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
46
Peptide A name
DNA polymerase delta catalytic subunit
Peptide B name
Proliferating cell nuclear antigen
Peptide A accession
P28340
Peptide B accession
P12004
Peptide A residue number
1011
Peptide B residue number
27

Ligandability

Cysteine 1011 of DNA polymerase delta catalytic subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Proliferating cell nuclear antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Proliferating cell nuclear antigen between cysteines 135 and 162.

Details

Redox score ?
80
PDB code
1ul1
Structure name
crystal structure of the human fen1-pcna complex
Structure deposition date
2003-09-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
62
Peptide accession
P12004
Residue number A
135
Residue number B
162
Peptide name
Proliferating cell nuclear antigen

Ligandability

Cysteine 135 of Proliferating cell nuclear antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 162 of Proliferating cell nuclear antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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