Coagulation factor V
Intramolecular
Cysteine 1907 and cysteine 2061
Cysteine 248 and cysteine 329
Cysteine 1712 and cysteine 1738
Cysteine 167 and cysteine 193
Cysteine 1725 and cysteine 1751
Cysteine 500 and cysteine 526 L
Cysteine 2053 and cysteine 2208
7kxy B 1879 B 2033
A redox-regulated disulphide may form within Coagulation factor V between cysteines 1907 and 2061 (1879 and 2033 respectively in this structure).
Details
Redox score ?
85
PDB code
7kxy
Structure name
cryo-em structure of human factor va at 4
Structure deposition date
2020-12-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12259
Residue number A
1907
Residue number B
2061
Peptide name
Coagulation factor V
Ligandability
Cysteine 1907 of Coagulation factor V
Cysteine 2061 of Coagulation factor V
7tpq C 220 C 301
A redox-regulated disulphide may form within Coagulation factor V between cysteines 248 and 329 (220 and 301 respectively in this structure).
Details
Redox score ?
82
PDB code
7tpq
Structure name
cryo-em structure of human prothrombinase on a nanodisc at 5
Structure deposition date
2022-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12259
Residue number A
248
Residue number B
329
Peptide name
Coagulation factor V
Ligandability
Cysteine 248 of Coagulation factor V
Cysteine 329 of Coagulation factor V
1sdd B 1684 B 1710
A redox-regulated disulphide may form within Coagulation factor V between cysteines 1712 and 1738 (1684 and 1710 respectively in this structure).
Details
Redox score ?
82
PDB code
1sdd
Structure name
crystal structure of bovine factor vai
Structure deposition date
2004-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q28107
Residue number A
1712
Residue number B
1738
Peptide name
Coagulation factor V
Ligandability
Cysteine 1712 of Coagulation factor V
Cysteine 1738 of Coagulation factor V
1sdd A 139 A 165
A redox-regulated disulphide may form within Coagulation factor V between cysteines 167 and 193 (139 and 165 respectively in this structure).
Details
Redox score ?
81
PDB code
1sdd
Structure name
crystal structure of bovine factor vai
Structure deposition date
2004-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q28107
Residue number A
167
Residue number B
193
Peptide name
Coagulation factor V
Ligandability
Cysteine 167 of Coagulation factor V
Cysteine 193 of Coagulation factor V
7kvf B 1697 B 1723
A redox-regulated disulphide may form within Coagulation factor V between cysteines 1725 and 1751 (1697 and 1723 respectively in this structure).
Details
Redox score ?
81
PDB code
7kvf
Structure name
cryo-em structure of human factor v at 3
Structure deposition date
2020-11-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12259
Residue number A
1725
Residue number B
1751
Peptide name
Coagulation factor V
Ligandability
Cysteine 1725 of Coagulation factor V
Cysteine 1751 of Coagulation factor V
7tpq C 472 C 498
A redox-regulated disulphide may form within Coagulation factor V between cysteines 500 and 526 (472 and 498 respectively in this structure).
Details
Redox score ?
80
PDB code
7tpq
Structure name
cryo-em structure of human prothrombinase on a nanodisc at 5
Structure deposition date
2022-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12259
Residue number A
500
Residue number B
526
Peptide name
Coagulation factor V
Ligandability
Cysteine 500 of Coagulation factor V
Cysteine 526 of Coagulation factor V
1sdd B 2025 B 2180
A redox-regulated disulphide may form within Coagulation factor V between cysteines 2053 and 2208 (2025 and 2180 respectively in this structure).
Details
Redox score ?
80
PDB code
1sdd
Structure name
crystal structure of bovine factor vai
Structure deposition date
2004-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q28107
Residue number A
2053
Residue number B
2208
Peptide name
Coagulation factor V
Ligandability
Cysteine 2053 of Coagulation factor V
Cysteine 2208 of Coagulation factor V
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