ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Low affinity immunoglobulin gamma Fc region receptor II-a

Intramolecular
Cysteine 62 and cysteine 104
Cysteine 143 and cysteine 187
A redox-regulated disulphide may form within Low affinity immunoglobulin gamma Fc region receptor II-a between cysteines 62 and 104 (26 and 68 respectively in this structure).

Details

Redox score ?
82
PDB code
1h9v
Structure name
human fc-gamma-receptor iia (fcgriia), monoclinic
Structure deposition date
2001-03-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12318
Residue number A
62
Residue number B
104
Peptide name
Low affinity immunoglobulin gamma Fc region receptor II-a

Ligandability

Cysteine 62 of Low affinity immunoglobulin gamma Fc region receptor II-a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Low affinity immunoglobulin gamma Fc region receptor II-a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Low affinity immunoglobulin gamma Fc region receptor II-a between cysteines 143 and 187 (107 and 151 respectively in this structure).

Details

Redox score ?
82
PDB code
3d5o
Structure name
structural recognition and functional activation of fcrr by innate pentraxins
Structure deposition date
2008-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12318
Residue number A
143
Residue number B
187
Peptide name
Low affinity immunoglobulin gamma Fc region receptor II-a

Ligandability

Cysteine 143 of Low affinity immunoglobulin gamma Fc region receptor II-a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Low affinity immunoglobulin gamma Fc region receptor II-a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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