a tool for identifying drug-targetable redox-active disulphides

Creatine kinase U-type, mitochondrial

Intramolecular

Cysteine 62 and cysteine 316 L

A redox-regulated disulphide may form within Creatine kinase U-type, mitochondrial between cysteines 62 and 316 (24 and 278 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

33

PDB code

Structure name

crystal structure of human ubiquitous mitochondrial creatine kinase

Structure deposition date

1999-07-08

Thiol separation (Å)

9

Half-sphere exposure sum ?

76

Minimum pK_a ?

10

% buried

76

Peptide accession

Residue number A

62

Residue number B

316

Peptide name

Creatine kinase U-type, mitochondrial

Ligandability

Cysteine 62 of Creatine kinase U-type, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 316 of Creatine kinase U-type, mitochondrial

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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