Granzyme A
Intermolecular
Cysteine 105 and cysteine 105
Intramolecular
Cysteine 54 and cysteine 70
Cysteine 148 and cysteine 218
Cysteine 208 and cysteine 234
Cysteine 179 and cysteine 197
1op8 E 93 F 93
A redox-regulated disulphide may form between two units of Granzyme A at cysteines 105 and 105 (93 and 93 respectively in this structure).
Details
Redox score ?
82
PDB code
1op8
Structure name
crystal structure of human granzyme a
Structure deposition date
2003-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide A name
Granzyme A
Peptide B name
Granzyme A
Peptide A accession
P12544
Peptide B accession
P12544
Peptide A residue number
105
Peptide B residue number
105
Ligandability
1op8 B 42 B 58
A redox-regulated disulphide may form within Granzyme A between cysteines 54 and 70 (42 and 58 respectively in this structure).
Details
Redox score ?
81
PDB code
1op8
Structure name
crystal structure of human granzyme a
Structure deposition date
2003-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12544
Residue number A
54
Residue number B
70
Peptide name
Granzyme A
Ligandability
Cysteine 54 of Granzyme A
Cysteine 70 of Granzyme A
1op8 B 136 B 201
A redox-regulated disulphide may form within Granzyme A between cysteines 148 and 218 (136 and 201 respectively in this structure).
Details
Redox score ?
81
PDB code
1op8
Structure name
crystal structure of human granzyme a
Structure deposition date
2003-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12544
Residue number A
148
Residue number B
218
Peptide name
Granzyme A
Ligandability
Cysteine 148 of Granzyme A
Cysteine 218 of Granzyme A
1op8 F 191 F 220
A redox-regulated disulphide may form within Granzyme A between cysteines 208 and 234 (191 and 220 respectively in this structure).
Details
Redox score ?
80
PDB code
1op8
Structure name
crystal structure of human granzyme a
Structure deposition date
2003-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12544
Residue number A
208
Residue number B
234
Peptide name
Granzyme A
Ligandability
Cysteine 208 of Granzyme A
Cysteine 234 of Granzyme A
1op8 E 168 E 182
A redox-regulated disulphide may form within Granzyme A between cysteines 179 and 197 (168 and 182 respectively in this structure).
Details
Redox score ?
79
PDB code
1op8
Structure name
crystal structure of human granzyme a
Structure deposition date
2003-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P12544
Residue number A
179
Residue number B
197
Peptide name
Granzyme A
Ligandability
Cysteine 179 of Granzyme A
Cysteine 197 of Granzyme A
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