a tool for identifying drug-targetable redox-active disulphides

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Intramolecular

Cysteine 234 and cysteine 264

A redox-regulated disulphide may form within 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial between cysteines 234 and 264 (189 and 219 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

19

PDB code

Structure name

crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine

Structure deposition date

2004-04-22

Thiol separation (Å)

10

Half-sphere exposure sum ?

101

Minimum pK_a ?

13

% buried

100

Peptide accession

Residue number A

234

Residue number B

264

Peptide name

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Ligandability

Cysteine 234 of 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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