ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Platelet glycoprotein Ib beta chain

Intramolecular
Cysteine 26 and cysteine 32
Cysteine 30 and cysteine 39
Cysteine 93 and cysteine 118
Cysteine 95 and cysteine 141
Cysteine 26 and cysteine 30
Cysteine 30 and cysteine 32
Cysteine 26 and cysteine 39
Cysteine 32 and cysteine 39
A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 26 and 32 (1 and 7 respectively in this structure).

Details

Redox score ?
89
PDB code
3rfe
Structure name
crystal structure of glycoprotein gpib ectodomain
Structure deposition date
2011-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
26
Residue number B
32
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 26 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 32 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 30 and 39 (5 and 14 respectively in this structure).

Details

Redox score ?
86
PDB code
3rfe
Structure name
crystal structure of glycoprotein gpib ectodomain
Structure deposition date
2011-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
30
Residue number B
39
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 30 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 39 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 93 and 118 (68 and 93 respectively in this structure).

Details

Redox score ?
82
PDB code
3rfe
Structure name
crystal structure of glycoprotein gpib ectodomain
Structure deposition date
2011-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
93
Residue number B
118
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 93 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 95 and 141 (70 and 116 respectively in this structure).

Details

Redox score ?
81
PDB code
3rfe
Structure name
crystal structure of glycoprotein gpib ectodomain
Structure deposition date
2011-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
95
Residue number B
141
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 95 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 26 and 30 (1 and 5 respectively in this structure).

Details

Redox score ?
66
PDB code
3rfe
Structure name
crystal structure of glycoprotein gpib ectodomain
Structure deposition date
2011-04-06
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
26
Residue number B
30
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 26 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 30 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 30 and 32 (5 and 7 respectively in this structure).

Details

Redox score ?
61
PDB code
3rez
Structure name
glycoprotein gpib variant
Structure deposition date
2011-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
30
Residue number B
32
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 30 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 32 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 26 and 39 (1 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
3rfe
Structure name
crystal structure of glycoprotein gpib ectodomain
Structure deposition date
2011-04-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
26
Residue number B
39
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 26 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 39 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein Ib beta chain between cysteines 32 and 39 (7 and 14 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3rez
Structure name
glycoprotein gpib variant
Structure deposition date
2011-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13224
Residue number A
32
Residue number B
39
Peptide name
Platelet glycoprotein Ib beta chain

Ligandability

Cysteine 32 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 39 of Platelet glycoprotein Ib beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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