ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-7

Intramolecular
Cysteine 59 and cysteine 154
Cysteine 72 and cysteine 166
A redox-regulated disulphide may form within Interleukin-7 between cysteines 59 and 154 (34 and 129 respectively in this structure).

Details

Redox score ?
87
PDB code
3di2
Structure name
crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
Structure deposition date
2008-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13232
Residue number A
59
Residue number B
154
Peptide name
Interleukin-7

Ligandability

Cysteine 59 of Interleukin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Interleukin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-7 between cysteines 72 and 166 (47 and 141 respectively in this structure).

Details

Redox score ?
86
PDB code
3di2
Structure name
crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
Structure deposition date
2008-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13232
Residue number A
72
Residue number B
166
Peptide name
Interleukin-7

Ligandability

Cysteine 72 of Interleukin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of Interleukin-7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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