Gamma-interferon-inducible lysosomal thiol reductase
Intermolecular
Cysteine 145 and cysteine 145
Cysteine 159 and cysteine 145
Intramolecular
Cysteine 114 and cysteine 121
Cysteine 223 and cysteine 235
Cysteine 129 and cysteine 175
Cysteine 69 and cysteine 72
6nwx A 145 B 145
A redox-regulated disulphide may form between two units of Gamma-interferon-inducible lysosomal thiol reductase at cysteines 145 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6nwx
Structure name
structure of mouse gilt, an enzyme involved in antigen processing
Structure deposition date
2019-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Gamma-interferon-inducible lysosomal thiol reductase
Peptide B name
Gamma-interferon-inducible lysosomal thiol reductase
Peptide A accession
Q9ESY9
Peptide B accession
Q9ESY9
Peptide A residue number
145
Peptide B residue number
145
Ligandability
6nwx A 159 B 145
A redox-regulated disulphide may form between two units of Gamma-interferon-inducible lysosomal thiol reductase at cysteines 159 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6nwx
Structure name
structure of mouse gilt, an enzyme involved in antigen processing
Structure deposition date
2019-02-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide A name
Gamma-interferon-inducible lysosomal thiol reductase
Peptide B name
Gamma-interferon-inducible lysosomal thiol reductase
Peptide A accession
Q9ESY9
Peptide B accession
Q9ESY9
Peptide A residue number
159
Peptide B residue number
145
Ligandability
Cysteine 159 of Gamma-interferon-inducible lysosomal thiol reductase
Cysteine 145 of Gamma-interferon-inducible lysosomal thiol reductase
6nwx A 114 A 121
A redox-regulated disulphide may form within Gamma-interferon-inducible lysosomal thiol reductase between cysteines 114 and 121.
Details
Redox score ?
85
PDB code
6nwx
Structure name
structure of mouse gilt, an enzyme involved in antigen processing
Structure deposition date
2019-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ESY9
Residue number A
114
Residue number B
121
Peptide name
Gamma-interferon-inducible lysosomal thiol reductase
Ligandability
Cysteine 114 of Gamma-interferon-inducible lysosomal thiol reductase
Cysteine 121 of Gamma-interferon-inducible lysosomal thiol reductase
6nwx A 223 A 235
A redox-regulated disulphide may form within Gamma-interferon-inducible lysosomal thiol reductase between cysteines 223 and 235.
Details
Redox score ?
84
PDB code
6nwx
Structure name
structure of mouse gilt, an enzyme involved in antigen processing
Structure deposition date
2019-02-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9ESY9
Residue number A
223
Residue number B
235
Peptide name
Gamma-interferon-inducible lysosomal thiol reductase
Ligandability
Cysteine 223 of Gamma-interferon-inducible lysosomal thiol reductase
Cysteine 235 of Gamma-interferon-inducible lysosomal thiol reductase
6nwx B 129 B 175
A redox-regulated disulphide may form within Gamma-interferon-inducible lysosomal thiol reductase between cysteines 129 and 175.
Details
Redox score ?
74
PDB code
6nwx
Structure name
structure of mouse gilt, an enzyme involved in antigen processing
Structure deposition date
2019-02-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
8
Peptide accession
Q9ESY9
Residue number A
129
Residue number B
175
Peptide name
Gamma-interferon-inducible lysosomal thiol reductase
Ligandability
Cysteine 129 of Gamma-interferon-inducible lysosomal thiol reductase
Cysteine 175 of Gamma-interferon-inducible lysosomal thiol reductase
6nwx B 69 B 72
A redox-regulated disulphide may form within Gamma-interferon-inducible lysosomal thiol reductase between cysteines 69 and 72. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6nwx
Structure name
structure of mouse gilt, an enzyme involved in antigen processing
Structure deposition date
2019-02-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
65
Minimum pKa ?
29
% buried
48
Peptide accession
Q9ESY9
Residue number A
69
Residue number B
72
Peptide name
Gamma-interferon-inducible lysosomal thiol reductase
Ligandability
Cysteine 69 of Gamma-interferon-inducible lysosomal thiol reductase
Cysteine 72 of Gamma-interferon-inducible lysosomal thiol reductase
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