ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Teratocarcinoma-derived growth factor

Intramolecular
Cysteine 99 and cysteine 117
Cysteine 115 and cysteine 124
Cysteine 112 and cysteine 133
Cysteine 117 and cysteine 124
Cysteine 115 and cysteine 117
Cysteine 99 and cysteine 124
Cysteine 99 and cysteine 115
A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 99 and 117 (4 and 22 respectively in this structure).

Details

Redox score ?
88
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
99
Residue number B
117
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 99 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 115 and 124 (20 and 29 respectively in this structure).

Details

Redox score ?
86
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
115
Residue number B
124
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 115 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 112 and 133 (17 and 38 respectively in this structure).

Details

Redox score ?
86
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
112
Residue number B
133
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 112 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 133 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 117 and 124 (22 and 29 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
117
Residue number B
124
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 117 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 115 and 117 (20 and 22 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
115
Residue number B
117
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 115 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 117 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 99 and 124 (4 and 29 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
99
Residue number B
124
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 99 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teratocarcinoma-derived growth factor between cysteines 99 and 115 (4 and 20 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2j5h
Structure name
nmr analysis of mouse cripto cfc domain
Structure deposition date
2006-09-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
P51865
Residue number A
99
Residue number B
115
Peptide name
Teratocarcinoma-derived growth factor

Ligandability

Cysteine 99 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Teratocarcinoma-derived growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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