ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysosome-associated membrane glycoprotein 2

Intermolecular
Cysteine 188 of HLA class I histocompatibility antigen, A alpha chain and cysteine 426 L
Cysteine 125 of HLA class I histocompatibility antigen, A alpha chain and cysteine 426
Intramolecular
Cysteine 37 and cysteine 75
Cysteine 149 and cysteine 185
A redox-regulated disulphide may form between cysteine 188 of HLA class I histocompatibility antigen, A alpha chain and cysteine 426 of Latent membrane protein 2 (164 and 1 respectively in this structure).

Details

Redox score ?
62
PDB code
3rew
Structure name
crystal structure of an lmp2a-derived peptide bound to human class i mhc hla-a2
Structure deposition date
2011-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
HLA class I histocompatibility antigen, A alpha chain
Peptide B name
Latent membrane protein 2
Peptide A accession
P01892
Peptide B accession
P13285
Peptide A residue number
188
Peptide B residue number
426

Ligandability

Cysteine 188 of HLA class I histocompatibility antigen, A alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 426 of Latent membrane protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 125 of HLA class I histocompatibility antigen, A alpha chain and cysteine 426 of Latent membrane protein 2 (101 and 1 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3rew
Structure name
crystal structure of an lmp2a-derived peptide bound to human class i mhc hla-a2
Structure deposition date
2011-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
HLA class I histocompatibility antigen, A alpha chain
Peptide B name
Latent membrane protein 2
Peptide A accession
P01892
Peptide B accession
P13285
Peptide A residue number
125
Peptide B residue number
426

Ligandability

Cysteine 125 of HLA class I histocompatibility antigen, A alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 426 of Latent membrane protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosome-associated membrane glycoprotein 2 between cysteines 37 and 75.

Details

Redox score ?
88
PDB code
5gv3
Structure name
crystal structure of the membrane-distal domain of mouse lysosome- associated membrane protein 2 (lamp-2)
Structure deposition date
2016-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17047
Residue number A
37
Residue number B
75
Peptide name
Lysosome-associated membrane glycoprotein 2

Ligandability

Cysteine 37 of Lysosome-associated membrane glycoprotein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Lysosome-associated membrane glycoprotein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysosome-associated membrane glycoprotein 2 between cysteines 149 and 185.

Details

Redox score ?
87
PDB code
5gv3
Structure name
crystal structure of the membrane-distal domain of mouse lysosome- associated membrane protein 2 (lamp-2)
Structure deposition date
2016-09-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P17047
Residue number A
149
Residue number B
185
Peptide name
Lysosome-associated membrane glycoprotein 2

Ligandability

Cysteine 149 of Lysosome-associated membrane glycoprotein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Lysosome-associated membrane glycoprotein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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