ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ribonuclease inhibitor

Intermolecular
Cysteine 409 and cysteine 89 of Non-secretory ribonuclease
Cysteine 30 and cysteine 30
Cysteine 93 of Ribonuclease pancreatic and cysteine 409
Intramolecular
Cysteine 45 and cysteine 75
Cysteine 273 and cysteine 277
Cysteine 329 and cysteine 330
Cysteine 277 and cysteine 313
Cysteine 325 and cysteine 329 L
Cysteine 305 and cysteine 329
Cysteine 12 and cysteine 38 L
More...
Cysteine 95 and cysteine 96 L
Cysteine 248 and cysteine 277
Cysteine 330 and cysteine 380
Cysteine 216 and cysteine 220 L
Cysteine 305 and cysteine 330
Cysteine 220 and cysteine 248
Cysteine 102 and cysteine 152 L
Cysteine 159 and cysteine 209 L
Cysteine 154 and cysteine 204 L
Cysteine 216 and cysteine 266 L
Cysteine 325 and cysteine 375 L
Cysteine 45 and cysteine 95 L
Cysteine 152 and cysteine 209 L
Cysteine 273 and cysteine 323
Cysteine 277 and cysteine 305
Cysteine 215 and cysteine 251
Cysteine 329 and cysteine 357
Cysteine 216 and cysteine 248 L
Cysteine 362 and cysteine 387
Cysteine 102 and cysteine 134 L
Cysteine 152 and cysteine 159 L
Cysteine 33 and cysteine 57 L
Cysteine 191 and cysteine 216 L
Cysteine 330 and cysteine 362
Cysteine 159 and cysteine 191 L
Cysteine 387 and cysteine 409
Cysteine 300 and cysteine 325 L
Cysteine 329 and cysteine 380
Cysteine 191 and cysteine 220
Cysteine 371 and cysteine 375
A redox-regulated disulphide may form between cysteine 409 of Ribonuclease inhibitor and cysteine 89 of Non-secretory ribonuclease (408 and 62 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
nan
Peptide A name
Ribonuclease inhibitor
Peptide B name
Non-secretory ribonuclease
Peptide A accession
P13489
Peptide B accession
P10153
Peptide A residue number
409
Peptide B residue number
89

Ligandability

Cysteine 409 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Non-secretory ribonuclease

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Ribonuclease inhibitor at cysteines 30 and 30 (29 and 29 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
78
Peptide A name
Ribonuclease inhibitor
Peptide B name
Ribonuclease inhibitor
Peptide A accession
P13489
Peptide B accession
P13489
Peptide A residue number
30
Peptide B residue number
30

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 93 of Ribonuclease pancreatic and cysteine 409 of Ribonuclease inhibitor (65 and 408 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
nan
Peptide A name
Ribonuclease pancreatic
Peptide B name
Ribonuclease inhibitor
Peptide A accession
P07998
Peptide B accession
P13489
Peptide A residue number
93
Peptide B residue number
409

Ligandability

Cysteine 93 of Ribonuclease pancreatic

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 409 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 45 and 75 (44 and 74 respectively in this structure).

Details

Redox score ?
69
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
36
Peptide accession
P13489
Residue number A
45
Residue number B
75
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 45 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 75 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 273 and 277 (272 and 276 respectively in this structure).

Details

Redox score ?
69
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
9
% buried
82
Peptide accession
P13489
Residue number A
273
Residue number B
277
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 273 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 329 and 330 (328 and 329 respectively in this structure).

Details

Redox score ?
68
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
76
Peptide accession
P13489
Residue number A
329
Residue number B
330
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 329 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 277 and 313 (276 and 312 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
78
Peptide accession
P13489
Residue number A
277
Residue number B
313
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 277 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 325 and 329. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
3tsr
Structure name
x-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1
Structure deposition date
2011-09-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
66
Peptide accession
Q91VI7
Residue number A
325
Residue number B
329
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 329 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 305 and 329 (304 and 328 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
13
% buried
84
Peptide accession
P13489
Residue number A
305
Residue number B
329
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 305 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 329 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 12 and 38 (11 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
36
Peptide accession
P13489
Residue number A
12
Residue number B
38
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 12 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 38 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 95 and 96 (94 and 95 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
64
Peptide accession
P13489
Residue number A
95
Residue number B
96
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 95 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 248 and 277 (247 and 276 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
70
Peptide accession
P13489
Residue number A
248
Residue number B
277
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 248 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 330 and 380 (329 and 379 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
9
% buried
95
Peptide accession
P13489
Residue number A
330
Residue number B
380
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 330 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 216 and 220 (215 and 219 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
50
Peptide accession
P13489
Residue number A
216
Residue number B
220
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 216 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 305 and 330 (304 and 329 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
9
% buried
85
Peptide accession
P13489
Residue number A
305
Residue number B
330
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 305 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 220 and 248 (219 and 247 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
50
Peptide accession
P13489
Residue number A
220
Residue number B
248
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 220 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 102 and 152 (101 and 151 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
78
Peptide accession
P13489
Residue number A
102
Residue number B
152
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 102 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 159 and 209 (158 and 208 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
81
Peptide accession
P13489
Residue number A
159
Residue number B
209
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 159 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 154 and 204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1dfj
Structure name
ribonuclease inhibitor complexed with ribonuclease a
Structure deposition date
1996-06-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
74
Peptide accession
P10775
Residue number A
154
Residue number B
204
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 154 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 216 and 266 (215 and 265 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
81
Peptide accession
P13489
Residue number A
216
Residue number B
266
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 216 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 325 and 375. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3tsr
Structure name
x-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1
Structure deposition date
2011-09-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
85
Peptide accession
Q91VI7
Residue number A
325
Residue number B
375
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 45 and 95 (44 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
12
% buried
76
Peptide accession
P13489
Residue number A
45
Residue number B
95
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 45 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 152 and 209 (151 and 208 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
13
% buried
90
Peptide accession
P13489
Residue number A
152
Residue number B
209
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 152 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 209 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 273 and 323 (272 and 322 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
96
Peptide accession
P13489
Residue number A
273
Residue number B
323
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 273 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 277 and 305 (276 and 304 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
86
Peptide accession
P13489
Residue number A
277
Residue number B
305
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 277 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 305 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 215 and 251. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3tsr
Structure name
x-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1
Structure deposition date
2011-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
62
Peptide accession
Q91VI7
Residue number A
215
Residue number B
251
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 215 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 251 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 329 and 357. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3tsr
Structure name
x-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1
Structure deposition date
2011-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
72
Peptide accession
Q91VI7
Residue number A
329
Residue number B
357
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 329 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 216 and 248 (215 and 247 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
69
Peptide accession
P13489
Residue number A
216
Residue number B
248
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 216 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 362 and 387 (361 and 386 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
85
Peptide accession
P13489
Residue number A
362
Residue number B
387
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 362 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 102 and 134 (101 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
72
Peptide accession
P13489
Residue number A
102
Residue number B
134
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 102 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 152 and 159 (151 and 158 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
80
Peptide accession
P13489
Residue number A
152
Residue number B
159
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 152 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 33 and 57. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
1dfj
Structure name
ribonuclease inhibitor complexed with ribonuclease a
Structure deposition date
1996-06-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
69
Peptide accession
P10775
Residue number A
33
Residue number B
57
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 33 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 191 and 216 (190 and 215 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
90
Peptide accession
P13489
Residue number A
191
Residue number B
216
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 191 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 330 and 362 (329 and 361 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2bex
Structure name
crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Structure deposition date
2004-12-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
95
Peptide accession
P13489
Residue number A
330
Residue number B
362
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 330 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 362 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 159 and 191 (158 and 190 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
84
Peptide accession
P13489
Residue number A
159
Residue number B
191
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 159 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 191 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 387 and 409 (386 and 408 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1a4y
Structure name
ribonuclease inhibitor-angiogenin complex
Structure deposition date
1998-02-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
48
Peptide accession
P13489
Residue number A
387
Residue number B
409
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 387 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 409 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 300 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3tsr
Structure name
x-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1
Structure deposition date
2011-09-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
86
Peptide accession
Q91VI7
Residue number A
300
Residue number B
325
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 300 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 329 and 380 (328 and 379 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
86
Peptide accession
P13489
Residue number A
329
Residue number B
380
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 329 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 191 and 220 (190 and 219 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2q4g
Structure name
ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i
Structure deposition date
2007-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
68
Peptide accession
P13489
Residue number A
191
Residue number B
220
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 191 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 371 and 375. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1dfj
Structure name
ribonuclease inhibitor complexed with ribonuclease a
Structure deposition date
1996-06-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
94
Peptide accession
P10775
Residue number A
371
Residue number B
375
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 371 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: