C-C motif chemokine 5
Intermolecular
Cysteine 33 and cysteine 33
Cysteine 20 of C-C chemokine receptor type 5 and cysteine 33
Cysteine 34 and cysteine 57
Cysteine 57 and cysteine 57
Cysteine 269 of C-C chemokine receptor type 5 and cysteine 33
Cysteine 20 of C-C chemokine receptor type 5 and cysteine 57
Cysteine 20 of C-C chemokine receptor type 5 and cysteine 34
Cysteine 20 of C-C chemokine receptor type 5 and cysteine 73
Cysteine 269 of C-C chemokine receptor type 5 and cysteine 73
Intramolecular
Cysteine 33 and cysteine 57
More...Cysteine 34 and cysteine 73
Cysteine 33 and cysteine 34
Cysteine 57 and cysteine 73
Cysteine 33 and cysteine 73
6aez B 11 C 11
A redox-regulated disulphide may form between two units of C-C motif chemokine 5 at cysteines 33 and 33 (11 and 11 respectively in this structure).
Details
Redox score ?
68
PDB code
6aez
Structure name
crystal structure of human ccl5 trimer
Structure deposition date
2018-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P13501
Peptide B accession
P13501
Peptide A residue number
33
Peptide B residue number
33
Ligandability
5uiw A 20 B 10
A redox-regulated disulphide may form between cysteine 20 of C-C chemokine receptor type 5 and cysteine 33 of C-C motif chemokine 5 (20 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
5uiw
Structure name
crystal structure of cc chemokine receptor 5 (ccr5) in complex with high potency hiv entry inhibitor 5p7-ccl5
Structure deposition date
2017-01-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P51681
Peptide B accession
P13501
Peptide A residue number
20
Peptide B residue number
33
Ligandability
Cysteine 20 of C-C chemokine receptor type 5
Cysteine 33 of C-C motif chemokine 5
1hrj A 11 B 34
A redox-regulated disulphide may form between two units of C-C motif chemokine 5 at cysteines 34 and 57 (11 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
1hrj
Structure name
human rantes, nmr, 13 structures
Structure deposition date
1995-08-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P13501
Peptide B accession
P13501
Peptide A residue number
34
Peptide B residue number
57
Ligandability
Cysteine 34 of C-C motif chemokine 5
Cysteine 57 of C-C motif chemokine 5
6c6d C 34 D 34
A redox-regulated disulphide may form between two units of C-C motif chemokine 5 at cysteines 57 and 57 (34 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6c6d
Structure name
20mer crystal structure of cc chemokine 5 (ccl5)
Structure deposition date
2018-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C motif chemokine 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P13501
Peptide B accession
P13501
Peptide A residue number
57
Peptide B residue number
57
Ligandability
5uiw A 269 B 10
A redox-regulated disulphide may form between cysteine 269 of C-C chemokine receptor type 5 and cysteine 33 of C-C motif chemokine 5 (269 and 10 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5uiw
Structure name
crystal structure of cc chemokine receptor 5 (ccr5) in complex with high potency hiv entry inhibitor 5p7-ccl5
Structure deposition date
2017-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P51681
Peptide B accession
P13501
Peptide A residue number
269
Peptide B residue number
33
Ligandability
Cysteine 269 of C-C chemokine receptor type 5
Cysteine 33 of C-C motif chemokine 5
5uiw A 20 B 34
A redox-regulated disulphide may form between cysteine 20 of C-C chemokine receptor type 5 and cysteine 57 of C-C motif chemokine 5 (20 and 34 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5uiw
Structure name
crystal structure of cc chemokine receptor 5 (ccr5) in complex with high potency hiv entry inhibitor 5p7-ccl5
Structure deposition date
2017-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P51681
Peptide B accession
P13501
Peptide A residue number
20
Peptide B residue number
57
Ligandability
Cysteine 20 of C-C chemokine receptor type 5
Cysteine 57 of C-C motif chemokine 5
5uiw A 20 B 11
A redox-regulated disulphide may form between cysteine 20 of C-C chemokine receptor type 5 and cysteine 34 of C-C motif chemokine 5 (20 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5uiw
Structure name
crystal structure of cc chemokine receptor 5 (ccr5) in complex with high potency hiv entry inhibitor 5p7-ccl5
Structure deposition date
2017-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P51681
Peptide B accession
P13501
Peptide A residue number
20
Peptide B residue number
34
Ligandability
Cysteine 20 of C-C chemokine receptor type 5
Cysteine 34 of C-C motif chemokine 5
5uiw A 20 B 50
A redox-regulated disulphide may form between cysteine 20 of C-C chemokine receptor type 5 and cysteine 73 of C-C motif chemokine 5 (20 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5uiw
Structure name
crystal structure of cc chemokine receptor 5 (ccr5) in complex with high potency hiv entry inhibitor 5p7-ccl5
Structure deposition date
2017-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P51681
Peptide B accession
P13501
Peptide A residue number
20
Peptide B residue number
73
Ligandability
Cysteine 20 of C-C chemokine receptor type 5
Cysteine 73 of C-C motif chemokine 5
5uiw A 269 B 50
A redox-regulated disulphide may form between cysteine 269 of C-C chemokine receptor type 5 and cysteine 73 of C-C motif chemokine 5 (269 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5uiw
Structure name
crystal structure of cc chemokine receptor 5 (ccr5) in complex with high potency hiv entry inhibitor 5p7-ccl5
Structure deposition date
2017-01-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
C-C chemokine receptor type 5
Peptide B name
C-C motif chemokine 5
Peptide A accession
P51681
Peptide B accession
P13501
Peptide A residue number
269
Peptide B residue number
73
Ligandability
Cysteine 269 of C-C chemokine receptor type 5
Cysteine 73 of C-C motif chemokine 5
2l9h B 10 B 34
A redox-regulated disulphide may form within C-C motif chemokine 5 between cysteines 33 and 57 (10 and 34 respectively in this structure).
Details
Redox score ?
84
PDB code
2l9h
Structure name
oligomeric structure of the chemokine ccl5/rantes from nmr, ms, and saxs data
Structure deposition date
2011-02-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
34
Peptide accession
P13501
Residue number A
33
Residue number B
57
Peptide name
C-C motif chemokine 5
Ligandability
Cysteine 33 of C-C motif chemokine 5
Cysteine 57 of C-C motif chemokine 5
5dnf B 11 B 50
A redox-regulated disulphide may form within C-C motif chemokine 5 between cysteines 34 and 73 (11 and 50 respectively in this structure).
Details
Redox score ?
80
PDB code
5dnf
Structure name
crystal structure of cc chemokine 5 (ccl5) oligomer in complex with heparin
Structure deposition date
2015-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13501
Residue number A
34
Residue number B
73
Peptide name
C-C motif chemokine 5
Ligandability
Cysteine 34 of C-C motif chemokine 5
Cysteine 73 of C-C motif chemokine 5
6c6d M 10 M 11
A redox-regulated disulphide may form within C-C motif chemokine 5 between cysteines 33 and 34 (10 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6c6d
Structure name
20mer crystal structure of cc chemokine 5 (ccl5)
Structure deposition date
2018-01-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13501
Residue number A
33
Residue number B
34
Peptide name
C-C motif chemokine 5
Ligandability
Cysteine 33 of C-C motif chemokine 5
Cysteine 34 of C-C motif chemokine 5
6c6d A 34 A 50
A redox-regulated disulphide may form within C-C motif chemokine 5 between cysteines 57 and 73 (34 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6c6d
Structure name
20mer crystal structure of cc chemokine 5 (ccl5)
Structure deposition date
2018-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13501
Residue number A
57
Residue number B
73
Peptide name
C-C motif chemokine 5
Ligandability
Cysteine 57 of C-C motif chemokine 5
Cysteine 73 of C-C motif chemokine 5
5dnf F 10 F 50
A redox-regulated disulphide may form within C-C motif chemokine 5 between cysteines 33 and 73 (10 and 50 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5dnf
Structure name
crystal structure of cc chemokine 5 (ccl5) oligomer in complex with heparin
Structure deposition date
2015-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13501
Residue number A
33
Residue number B
73
Peptide name
C-C motif chemokine 5
Ligandability
Cysteine 33 of C-C motif chemokine 5
Cysteine 73 of C-C motif chemokine 5
If this tool was useful for finding a disulphide, please cite: