ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Oncostatin-M

Intramolecular
Cysteine 31 and cysteine 152
Cysteine 74 and cysteine 192
A redox-regulated disulphide may form within Oncostatin-M between cysteines 31 and 152 (6 and 127 respectively in this structure).

Details

Redox score ?
87
PDB code
1evs
Structure name
crystal structure of human oncostatin m
Structure deposition date
2000-04-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13725
Residue number A
31
Residue number B
152
Peptide name
Oncostatin-M

Ligandability

Cysteine 31 of Oncostatin-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 152 of Oncostatin-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Oncostatin-M between cysteines 74 and 192 (49 and 167 respectively in this structure).

Details

Redox score ?
85
PDB code
1evs
Structure name
crystal structure of human oncostatin m
Structure deposition date
2000-04-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13725
Residue number A
74
Residue number B
192
Peptide name
Oncostatin-M

Ligandability

Cysteine 74 of Oncostatin-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of Oncostatin-M

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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