ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

HLA class I histocompatibility antigen, alpha chain E

Intramolecular
Cysteine 122 and cysteine 185 L
Cysteine 224 and cysteine 280
A redox-regulated disulphide may form within HLA class I histocompatibility antigen, alpha chain E between cysteines 122 and 185 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
6gh1
Structure name
hla-e*01:03 in complex with mtb44
Structure deposition date
2018-05-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
E2G051
Residue number A
122
Residue number B
185
Peptide name
HLA class I histocompatibility antigen, alpha chain E

Ligandability

Cysteine 122 of HLA class I histocompatibility antigen, alpha chain E

Cysteine 185 of HLA class I histocompatibility antigen, alpha chain E

A redox-regulated disulphide may form within HLA class I histocompatibility antigen, alpha chain E between cysteines 224 and 280 (203 and 259 respectively in this structure).

Details

Redox score ?
81
PDB code
6ggm
Structure name
hla-e*01:03 in complex with the mtb44 peptide variant: mtb44*p2-phe
Structure deposition date
2018-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
E2G051
Residue number A
224
Residue number B
280
Peptide name
HLA class I histocompatibility antigen, alpha chain E

Ligandability

Cysteine 224 of HLA class I histocompatibility antigen, alpha chain E

Cysteine 280 of HLA class I histocompatibility antigen, alpha chain E

If this tool was useful for finding a disulphide, please cite: