ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II histocompatibility antigen, DO beta chain

Intramolecular
Cysteine 41 and cysteine 105
Cysteine 143 and cysteine 199
A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DO beta chain between cysteines 41 and 105 (15 and 79 respectively in this structure).

Details

Redox score ?
80
PDB code
4i0p
Structure name
hla-do in complex with hla-dm
Structure deposition date
2012-11-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13765
Residue number A
41
Residue number B
105
Peptide name
HLA class II histocompatibility antigen, DO beta chain

Ligandability

Cysteine 41 of HLA class II histocompatibility antigen, DO beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of HLA class II histocompatibility antigen, DO beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DO beta chain between cysteines 143 and 199 (117 and 173 respectively in this structure).

Details

Redox score ?
79
PDB code
4i0p
Structure name
hla-do in complex with hla-dm
Structure deposition date
2012-11-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13765
Residue number A
143
Residue number B
199
Peptide name
HLA class II histocompatibility antigen, DO beta chain

Ligandability

Cysteine 143 of HLA class II histocompatibility antigen, DO beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of HLA class II histocompatibility antigen, DO beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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