ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Electron transfer flavoprotein subunit alpha, mitochondrial

Intermolecular
Cysteine 155 and cysteine 131 of Electron transfer flavoprotein subunit beta L
Intramolecular
Cysteine 53 and cysteine 68
Cysteine 53 and cysteine 109
A redox-regulated disulphide may form between cysteine 155 of Electron transfer flavoprotein subunit alpha, mitochondrial and cysteine 131 of Electron transfer flavoprotein subunit beta. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2a1u
Structure name
crystal structure of the human etf e165betaa mutant
Structure deposition date
2005-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
92
Peptide A name
Electron transfer flavoprotein subunit alpha, mitochondrial
Peptide B name
Electron transfer flavoprotein subunit beta
Peptide A accession
P13804
Peptide B accession
P38117
Peptide A residue number
155
Peptide B residue number
131

Ligandability

Cysteine 155 of Electron transfer flavoprotein subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 131 of Electron transfer flavoprotein subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Electron transfer flavoprotein subunit alpha, mitochondrial between cysteines 53 and 68. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1t9g
Structure name
structure of the human mcad:etf complex
Structure deposition date
2004-05-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
58
Peptide accession
P13804
Residue number A
53
Residue number B
68
Peptide name
Electron transfer flavoprotein subunit alpha, mitochondrial

Ligandability

Cysteine 53 of Electron transfer flavoprotein subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 68 of Electron transfer flavoprotein subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Electron transfer flavoprotein subunit alpha, mitochondrial between cysteines 53 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
2a1u
Structure name
crystal structure of the human etf e165betaa mutant
Structure deposition date
2005-06-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
12
% buried
100
Peptide accession
P13804
Residue number A
53
Residue number B
109
Peptide name
Electron transfer flavoprotein subunit alpha, mitochondrial

Ligandability

Cysteine 53 of Electron transfer flavoprotein subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Electron transfer flavoprotein subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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