ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Intermolecular
Cysteine 166 and cysteine 166
A redox-regulated disulphide may form between two units of Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial at cysteines 166 and 166.

Details

Redox score ?
73
PDB code
7ehv
Structure name
human mthfd2 in complex with compound 21 and 3
Structure deposition date
2021-03-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
92
Minimum pKa ?
8
% buried
100
Peptide A name
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Peptide B name
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Peptide A accession
P13995
Peptide B accession
P13995
Peptide A residue number
166
Peptide B residue number
166

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: