ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

17-beta-hydroxysteroid dehydrogenase type 1

Intramolecular
Cysteine 90 and cysteine 167
A redox-regulated disulphide may form within 17-beta-hydroxysteroid dehydrogenase type 1 between cysteines 90 and 167 (89 and 166 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
1fdu
Structure name
human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant h221l complexed with estradiol and nadp+
Structure deposition date
1998-01-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
P14061
Residue number A
90
Residue number B
167
Peptide name
17-beta-hydroxysteroid dehydrogenase type 1

Ligandability

Cysteine 90 of 17-beta-hydroxysteroid dehydrogenase type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of 17-beta-hydroxysteroid dehydrogenase type 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: