Endothelin-3
Intermolecular
Cysteine 358 of Endothelin receptor type B and cysteine 107
Cysteine 255 of Endothelin receptor type B and cysteine 111
Intramolecular
Cysteine 97 and cysteine 111
Cysteine 99 and cysteine 107
Cysteine 99 and cysteine 111
Cysteine 97 and cysteine 99
Cysteine 97 and cysteine 107
Cysteine 107 and cysteine 111
6igk A 358 B 11
A redox-regulated disulphide may form between cysteine 358 of Endothelin receptor type B and cysteine 107 of Endothelin-3 (358 and 11 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide A name
Endothelin receptor type B
Peptide B name
Endothelin-3
Peptide A accession
P24530
Peptide B accession
P14138
Peptide A residue number
358
Peptide B residue number
107
Ligandability
Cysteine 358 of Endothelin receptor type B
Cysteine 107 of Endothelin-3
6igk A 255 B 15
A redox-regulated disulphide may form between cysteine 255 of Endothelin receptor type B and cysteine 111 of Endothelin-3 (255 and 15 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide A name
Endothelin receptor type B
Peptide B name
Endothelin-3
Peptide A accession
P24530
Peptide B accession
P14138
Peptide A residue number
255
Peptide B residue number
111
Ligandability
Cysteine 255 of Endothelin receptor type B
Cysteine 111 of Endothelin-3
6igk B 1 B 15
A redox-regulated disulphide may form within Endothelin-3 between cysteines 97 and 111 (1 and 15 respectively in this structure).
Details
Redox score ?
85
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14138
Residue number A
97
Residue number B
111
Peptide name
Endothelin-3
Ligandability
Cysteine 97 of Endothelin-3
Cysteine 111 of Endothelin-3
6igk B 3 B 11
A redox-regulated disulphide may form within Endothelin-3 between cysteines 99 and 107 (3 and 11 respectively in this structure).
Details
Redox score ?
82
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14138
Residue number A
99
Residue number B
107
Peptide name
Endothelin-3
Ligandability
Cysteine 99 of Endothelin-3
Cysteine 107 of Endothelin-3
6igk B 3 B 15
A redox-regulated disulphide may form within Endothelin-3 between cysteines 99 and 111 (3 and 15 respectively in this structure).
Details
Redox score ?
71
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14138
Residue number A
99
Residue number B
111
Peptide name
Endothelin-3
Ligandability
Cysteine 99 of Endothelin-3
Cysteine 111 of Endothelin-3
6igk B 1 B 3
A redox-regulated disulphide may form within Endothelin-3 between cysteines 97 and 99 (1 and 3 respectively in this structure).
Details
Redox score ?
69
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14138
Residue number A
97
Residue number B
99
Peptide name
Endothelin-3
Ligandability
Cysteine 97 of Endothelin-3
Cysteine 99 of Endothelin-3
6igk B 1 B 11
A redox-regulated disulphide may form within Endothelin-3 between cysteines 97 and 107 (1 and 11 respectively in this structure).
Details
Redox score ?
65
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14138
Residue number A
97
Residue number B
107
Peptide name
Endothelin-3
Ligandability
Cysteine 97 of Endothelin-3
Cysteine 107 of Endothelin-3
6igk B 11 B 15
A redox-regulated disulphide may form within Endothelin-3 between cysteines 107 and 111 (11 and 15 respectively in this structure).
Details
Redox score ?
63
PDB code
6igk
Structure name
crystal structure of human etb receptor in complex with endothelin-3
Structure deposition date
2018-09-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14138
Residue number A
107
Residue number B
111
Peptide name
Endothelin-3
Ligandability
Cysteine 107 of Endothelin-3
Cysteine 111 of Endothelin-3
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