ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hepatocyte growth factor

Intermolecular
Cysteine 487 and cysteine 604
Cysteine 207 and cysteine 207
Cysteine 129 and cysteine 129
Cysteine 128 and cysteine 206
Cysteine 487 and cysteine 679
Cysteine 212 and cysteine 212
Intramolecular
Cysteine 391 and cysteine 469
Cysteine 305 and cysteine 383
Cysteine 412 and cysteine 452
Cysteine 211 and cysteine 206
More...
Cysteine 260 and cysteine 283
Cysteine 177 and cysteine 201 L
Cysteine 326 and cysteine 365
Cysteine 440 and cysteine 464
Cysteine 149 and cysteine 189
Cysteine 612 and cysteine 679
Cysteine 354 and cysteine 377
Cysteine 669 and cysteine 697
Cysteine 519 and cysteine 535
Cysteine 74 and cysteine 84
Cysteine 232 and cysteine 271
Cysteine 642 and cysteine 658
Cysteine 70 and cysteine 96
Cysteine 365 and cysteine 377
Cysteine 189 and cysteine 201
Cysteine 149 and cysteine 177 L
Cysteine 271 and cysteine 283
Cysteine 149 and cysteine 201
Cysteine 232 and cysteine 260
Cysteine 232 and cysteine 283
Cysteine 354 and cysteine 365
Cysteine 177 and cysteine 189 L
Cysteine 260 and cysteine 271
Cysteine 326 and cysteine 354
Cysteine 412 and cysteine 464
Cysteine 440 and cysteine 452
Cysteine 326 and cysteine 377
Cysteine 452 and cysteine 464
Cysteine 412 and cysteine 440
Cysteine 70 and cysteine 74
A redox-regulated disulphide may form between two units of Hepatocyte growth factor at cysteines 487 and 604.

Details

Redox score ?
86
PDB code
6lz9
Structure name
t8e4 antibody fab complexed with the active form of hgf
Structure deposition date
2020-02-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor
Peptide B name
Hepatocyte growth factor
Peptide A accession
P14210
Peptide B accession
P14210
Peptide A residue number
487
Peptide B residue number
604

Ligandability

Cysteine 487 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 604 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Hepatocyte growth factor at cysteines 207 and 207.

Details

Redox score ?
72
PDB code
2qj4
Structure name
a mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Structure deposition date
2007-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor
Peptide B name
Hepatocyte growth factor
Peptide A accession
Q08048
Peptide B accession
Q08048
Peptide A residue number
207
Peptide B residue number
207

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Hepatocyte growth factor at cysteines 129 and 129.

Details

Redox score ?
68
PDB code
2qj4
Structure name
a mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Structure deposition date
2007-07-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor
Peptide B name
Hepatocyte growth factor
Peptide A accession
Q08048
Peptide B accession
Q08048
Peptide A residue number
129
Peptide B residue number
129

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Hepatocyte growth factor at cysteines 128 and 206.

Details

Redox score ?
67
PDB code
3mkp
Structure name
crystal structure of 1k1 mutant of hepatocyte growth factor/scatter factor fragment nk1 in complex with heparin
Structure deposition date
2010-04-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor
Peptide B name
Hepatocyte growth factor
Peptide A accession
P14210
Peptide B accession
P14210
Peptide A residue number
128
Peptide B residue number
206

Ligandability

Cysteine 128 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Hepatocyte growth factor at cysteines 487 and 679. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6lz9
Structure name
t8e4 antibody fab complexed with the active form of hgf
Structure deposition date
2020-02-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor
Peptide B name
Hepatocyte growth factor
Peptide A accession
P14210
Peptide B accession
P14210
Peptide A residue number
487
Peptide B residue number
679

Ligandability

Cysteine 487 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Hepatocyte growth factor at cysteines 212 and 212. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4iua
Structure name
crystal structure of the nk2 fragment (31-290) of the mouse hepatocyte growth factor/scatter factor
Structure deposition date
2013-01-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide A name
Hepatocyte growth factor
Peptide B name
Hepatocyte growth factor
Peptide A accession
Q08048
Peptide B accession
Q08048
Peptide A residue number
212
Peptide B residue number
212

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 391 and 469.

Details

Redox score ?
90
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
391
Residue number B
469
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 391 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 469 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 305 and 383.

Details

Redox score ?
86
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
33
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
305
Residue number B
383
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 305 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 383 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 412 and 452.

Details

Redox score ?
84
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
412
Residue number B
452
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 412 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 211 and 206 (89 and 167 respectively in this structure).

Details

Redox score ?
84
PDB code
7ocl
Structure name
k1k1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Structure deposition date
2021-04-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
211
Residue number B
206
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 211 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 206 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 260 and 283.

Details

Redox score ?
84
PDB code
3hn4
Structure name
crystal structure of the nk2 fragment (28-289) of human hepatocyte growth factor/scatter factor
Structure deposition date
2009-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
260
Residue number B
283
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 260 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 177 and 201.

Details

Redox score ?
82
PDB code
1nk1
Structure name
nk1 fragment of human hepatocyte growth factor/scatter factor (hgf/sf) at 2
Structure deposition date
1998-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
177
Residue number B
201
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 177 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 326 and 365.

Details

Redox score ?
82
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
326
Residue number B
365
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 326 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 440 and 464.

Details

Redox score ?
81
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
440
Residue number B
464
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 440 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 149 and 189.

Details

Redox score ?
81
PDB code
5ct3
Structure name
the structure of the nk1 fragment of hgf/sf complexed with 2fa
Structure deposition date
2015-07-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
149
Residue number B
189
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 149 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 612 and 679.

Details

Redox score ?
81
PDB code
6lz9
Structure name
t8e4 antibody fab complexed with the active form of hgf
Structure deposition date
2020-02-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
612
Residue number B
679
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 612 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 679 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 354 and 377.

Details

Redox score ?
81
PDB code
7moa
Structure name
cryo-em structure of the c-met ii/hgf i complex bound with hgf ii in a rigid conformation
Structure deposition date
2021-05-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
354
Residue number B
377
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 354 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 669 and 697.

Details

Redox score ?
81
PDB code
6lz9
Structure name
t8e4 antibody fab complexed with the active form of hgf
Structure deposition date
2020-02-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
669
Residue number B
697
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 669 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 697 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 519 and 535.

Details

Redox score ?
80
PDB code
4k3j
Structure name
crystal structure of onartuzumab fab in complex with met and hgf-beta
Structure deposition date
2013-04-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
519
Residue number B
535
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 519 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 535 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 74 and 84 (374 and 384 respectively in this structure).

Details

Redox score ?
80
PDB code
1bht
Structure name
nk1 fragment of human hepatocyte growth factor
Structure deposition date
1998-06-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
74
Residue number B
84
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 74 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 232 and 271.

Details

Redox score ?
80
PDB code
3hn4
Structure name
crystal structure of the nk2 fragment (28-289) of human hepatocyte growth factor/scatter factor
Structure deposition date
2009-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
232
Residue number B
271
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 232 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 642 and 658.

Details

Redox score ?
80
PDB code
4o3t
Structure name
zymogen hgf-beta/met with zymogen activator peptide zap
Structure deposition date
2013-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
642
Residue number B
658
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 642 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 658 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 70 and 96.

Details

Redox score ?
76
PDB code
1gmn
Structure name
crystal structures of nk1-heparin complexes reveal the basis for nk1 activity and enable engineering of potent agonists of the met receptor
Structure deposition date
2001-09-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
88
Peptide accession
P14210
Residue number A
70
Residue number B
96
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 70 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 365 and 377.

Details

Redox score ?
73
PDB code
7moa
Structure name
cryo-em structure of the c-met ii/hgf i complex bound with hgf ii in a rigid conformation
Structure deposition date
2021-05-01
Thiol separation (Å)
3
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
365
Residue number B
377
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 365 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 189 and 201.

Details

Redox score ?
71
PDB code
1gp9
Structure name
a new crystal form of the nk1 splice variant of hgf/sf demonstrates extensive hinge movement and suggests that the nk1 dimer originates by domain swapping
Structure deposition date
2001-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
189
Residue number B
201
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 189 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 149 and 177 (110 and 138 respectively in this structure).

Details

Redox score ?
71
PDB code
7ocl
Structure name
k1k1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
Structure deposition date
2021-04-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
149
Residue number B
177
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 149 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 177 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 271 and 283.

Details

Redox score ?
71
PDB code
3sp8
Structure name
crystal structure of nk2 in complex with fractionated heparin dp10
Structure deposition date
2011-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
271
Residue number B
283
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 271 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 149 and 201 (1149 and 1201 respectively in this structure).

Details

Redox score ?
71
PDB code
2qj2
Structure name
a mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Structure deposition date
2007-07-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
149
Residue number B
201
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 149 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 232 and 260.

Details

Redox score ?
69
PDB code
3sp8
Structure name
crystal structure of nk2 in complex with fractionated heparin dp10
Structure deposition date
2011-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
232
Residue number B
260
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 232 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 232 and 283.

Details

Redox score ?
69
PDB code
3hn4
Structure name
crystal structure of the nk2 fragment (28-289) of human hepatocyte growth factor/scatter factor
Structure deposition date
2009-05-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
232
Residue number B
283
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 232 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 354 and 365.

Details

Redox score ?
68
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
354
Residue number B
365
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 354 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 365 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 177 and 189.

Details

Redox score ?
67
PDB code
1nk1
Structure name
nk1 fragment of human hepatocyte growth factor/scatter factor (hgf/sf) at 2
Structure deposition date
1998-08-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
177
Residue number B
189
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 177 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 260 and 271.

Details

Redox score ?
67
PDB code
3hn4
Structure name
crystal structure of the nk2 fragment (28-289) of human hepatocyte growth factor/scatter factor
Structure deposition date
2009-05-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
260
Residue number B
271
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 260 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 326 and 354.

Details

Redox score ?
60
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
326
Residue number B
354
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 326 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 354 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 412 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
412
Residue number B
464
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 412 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 440 and 452. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
440
Residue number B
452
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 440 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 452 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 326 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
326
Residue number B
377
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 326 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 452 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
452
Residue number B
464
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 452 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 412 and 440. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7mo7
Structure name
cryo-em structure of 2:2 c-met/hgf holo-complex
Structure deposition date
2021-05-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
412
Residue number B
440
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 412 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 440 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatocyte growth factor between cysteines 70 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3sp8
Structure name
crystal structure of nk2 in complex with fractionated heparin dp10
Structure deposition date
2011-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14210
Residue number A
70
Residue number B
74
Peptide name
Hepatocyte growth factor

Ligandability

Cysteine 70 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Hepatocyte growth factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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