Perforin-1
Intramolecular
Cysteine 30 and cysteine 72
Cysteine 376 and cysteine 392
Cysteine 380 and cysteine 394
Cysteine 22 and cysteine 75
Cysteine 396 and cysteine 406
Cysteine 524 and cysteine 533
Cysteine 496 and cysteine 509
Cysteine 241 and cysteine 407
Cysteine 101 and cysteine 175
Cysteine 256 and cysteine 278
More...Cysteine 406 and cysteine 407
Cysteine 241 and cysteine 406
Cysteine 376 and cysteine 394
Cysteine 394 and cysteine 406
Cysteine 396 and cysteine 407
Cysteine 392 and cysteine 394
Cysteine 380 and cysteine 406
Cysteine 241 and cysteine 396
Cysteine 376 and cysteine 380
Cysteine 394 and cysteine 396
Cysteine 380 and cysteine 392
Cysteine 380 and cysteine 396
Cysteine 72 and cysteine 75
3nsj A 30 A 72
A redox-regulated disulphide may form within Perforin-1 between cysteines 30 and 72.
Details
Redox score ?
87
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
30
Residue number B
72
Peptide name
Perforin-1
Ligandability
Cysteine 30 of Perforin-1
Cysteine 72 of Perforin-1
3nsj A 376 A 392
A redox-regulated disulphide may form within Perforin-1 between cysteines 376 and 392.
Details
Redox score ?
86
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
376
Residue number B
392
Peptide name
Perforin-1
Ligandability
Cysteine 376 of Perforin-1
Cysteine 392 of Perforin-1
3nsj A 380 A 394
A redox-regulated disulphide may form within Perforin-1 between cysteines 380 and 394.
Details
Redox score ?
86
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
380
Residue number B
394
Peptide name
Perforin-1
Ligandability
Cysteine 380 of Perforin-1
Cysteine 394 of Perforin-1
3nsj A 22 A 75
A redox-regulated disulphide may form within Perforin-1 between cysteines 22 and 75.
Details
Redox score ?
85
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
22
Residue number B
75
Peptide name
Perforin-1
Ligandability
Cysteine 22 of Perforin-1
Cysteine 75 of Perforin-1
3nsj A 396 A 406
A redox-regulated disulphide may form within Perforin-1 between cysteines 396 and 406.
Details
Redox score ?
85
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
396
Residue number B
406
Peptide name
Perforin-1
Ligandability
Cysteine 396 of Perforin-1
Cysteine 406 of Perforin-1
5ug7 A 524 A 533
A redox-regulated disulphide may form within Perforin-1 between cysteines 524 and 533.
Details
Redox score ?
85
PDB code
5ug7
Structure name
calcium bound perforin c2 domain - t431d
Structure deposition date
2017-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
524
Residue number B
533
Peptide name
Perforin-1
Ligandability
Cysteine 524 of Perforin-1
Cysteine 533 of Perforin-1
3nsj A 496 A 509
A redox-regulated disulphide may form within Perforin-1 between cysteines 496 and 509.
Details
Redox score ?
83
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
496
Residue number B
509
Peptide name
Perforin-1
Ligandability
Cysteine 496 of Perforin-1
Cysteine 509 of Perforin-1
3nsj A 241 A 407
A redox-regulated disulphide may form within Perforin-1 between cysteines 241 and 407.
Details
Redox score ?
80
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
241
Residue number B
407
Peptide name
Perforin-1
Ligandability
Cysteine 241 of Perforin-1
Cysteine 407 of Perforin-1
7pag A 101 A 175
A redox-regulated disulphide may form within Perforin-1 between cysteines 101 and 175.
Details
Redox score ?
78
PDB code
7pag
Structure name
the pore conformation of lymphocyte perforin
Structure deposition date
2021-07-29
Thiol separation (Å)
3
Half-sphere exposure sum ?
54
Minimum pKa ?
8
% buried
25
Peptide accession
P10820
Residue number A
101
Residue number B
175
Peptide name
Perforin-1
Ligandability
Cysteine 101 of Perforin-1
Cysteine 175 of Perforin-1
3nsj A 256 A 278
A redox-regulated disulphide may form within Perforin-1 between cysteines 256 and 278.
Details
Redox score ?
72
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
44
Peptide accession
P10820
Residue number A
256
Residue number B
278
Peptide name
Perforin-1
Ligandability
Cysteine 256 of Perforin-1
Cysteine 278 of Perforin-1
3nsj A 406 A 407
A redox-regulated disulphide may form within Perforin-1 between cysteines 406 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
406
Residue number B
407
Peptide name
Perforin-1
Ligandability
Cysteine 406 of Perforin-1
Cysteine 407 of Perforin-1
3nsj A 241 A 406
A redox-regulated disulphide may form within Perforin-1 between cysteines 241 and 406. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
241
Residue number B
406
Peptide name
Perforin-1
Ligandability
Cysteine 241 of Perforin-1
Cysteine 406 of Perforin-1
3nsj A 376 A 394
A redox-regulated disulphide may form within Perforin-1 between cysteines 376 and 394. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
376
Residue number B
394
Peptide name
Perforin-1
Ligandability
Cysteine 376 of Perforin-1
Cysteine 394 of Perforin-1
3nsj A 394 A 406
A redox-regulated disulphide may form within Perforin-1 between cysteines 394 and 406. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
394
Residue number B
406
Peptide name
Perforin-1
Ligandability
Cysteine 394 of Perforin-1
Cysteine 406 of Perforin-1
3nsj A 396 A 407
A redox-regulated disulphide may form within Perforin-1 between cysteines 396 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
396
Residue number B
407
Peptide name
Perforin-1
Ligandability
Cysteine 396 of Perforin-1
Cysteine 407 of Perforin-1
3nsj A 392 A 394
A redox-regulated disulphide may form within Perforin-1 between cysteines 392 and 394. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
392
Residue number B
394
Peptide name
Perforin-1
Ligandability
Cysteine 392 of Perforin-1
Cysteine 394 of Perforin-1
3nsj A 380 A 406
A redox-regulated disulphide may form within Perforin-1 between cysteines 380 and 406. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
380
Residue number B
406
Peptide name
Perforin-1
Ligandability
Cysteine 380 of Perforin-1
Cysteine 406 of Perforin-1
3nsj A 241 A 396
A redox-regulated disulphide may form within Perforin-1 between cysteines 241 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
241
Residue number B
396
Peptide name
Perforin-1
Ligandability
Cysteine 241 of Perforin-1
Cysteine 396 of Perforin-1
3nsj A 376 A 380
A redox-regulated disulphide may form within Perforin-1 between cysteines 376 and 380. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
376
Residue number B
380
Peptide name
Perforin-1
Ligandability
Cysteine 376 of Perforin-1
Cysteine 380 of Perforin-1
3nsj A 394 A 396
A redox-regulated disulphide may form within Perforin-1 between cysteines 394 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
394
Residue number B
396
Peptide name
Perforin-1
Ligandability
Cysteine 394 of Perforin-1
Cysteine 396 of Perforin-1
3nsj A 380 A 392
A redox-regulated disulphide may form within Perforin-1 between cysteines 380 and 392. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
380
Residue number B
392
Peptide name
Perforin-1
Ligandability
Cysteine 380 of Perforin-1
Cysteine 392 of Perforin-1
3nsj A 380 A 396
A redox-regulated disulphide may form within Perforin-1 between cysteines 380 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
380
Residue number B
396
Peptide name
Perforin-1
Ligandability
Cysteine 380 of Perforin-1
Cysteine 396 of Perforin-1
3nsj A 72 A 75
A redox-regulated disulphide may form within Perforin-1 between cysteines 72 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
3nsj
Structure name
the x-ray crystal structure of lymphocyte perforin
Structure deposition date
2010-07-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P10820
Residue number A
72
Residue number B
75
Peptide name
Perforin-1
Ligandability
Cysteine 72 of Perforin-1
Cysteine 75 of Perforin-1
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