Glucosidase 2 subunit beta
Intramolecular
Cysteine 97 and cysteine 112
Cysteine 77 and cysteine 99
Cysteine 56 and cysteine 70
Cysteine 39 and cysteine 58
Cysteine 100 and cysteine 116
Cysteine 58 and cysteine 70
Cysteine 56 and cysteine 58
Cysteine 99 and cysteine 112
Cysteine 99 and cysteine 100
Cysteine 39 and cysteine 56
More...Cysteine 77 and cysteine 100
Cysteine 39 and cysteine 70
Cysteine 97 and cysteine 99
Cysteine 77 and cysteine 112
Cysteine 99 and cysteine 116
Cysteine 77 and cysteine 116
8d43 B 97 B 112
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 97 and 112.
Details
Redox score ?
89
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14314
Residue number A
97
Residue number B
112
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 97 of Glucosidase 2 subunit beta
Cysteine 112 of Glucosidase 2 subunit beta
8d43 B 77 B 99
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 77 and 99.
Details
Redox score ?
84
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14314
Residue number A
77
Residue number B
99
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 77 of Glucosidase 2 subunit beta
Cysteine 99 of Glucosidase 2 subunit beta
7k9o B 56 B 70
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 56 and 70.
Details
Redox score ?
83
PDB code
7k9o
Structure name
co-crystal structure of alpha glucosidase with compound 3
Structure deposition date
2020-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
O08795
Residue number A
56
Residue number B
70
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 56 of Glucosidase 2 subunit beta
Cysteine 70 of Glucosidase 2 subunit beta
8d43 B 39 B 58
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 39 and 58.
Details
Redox score ?
82
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
8
% buried
26
Peptide accession
P14314
Residue number A
39
Residue number B
58
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 39 of Glucosidase 2 subunit beta
Cysteine 58 of Glucosidase 2 subunit beta
8d43 B 100 B 116
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 100 and 116.
Details
Redox score ?
79
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
P14314
Residue number A
100
Residue number B
116
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 100 of Glucosidase 2 subunit beta
Cysteine 116 of Glucosidase 2 subunit beta
5h9o B 58 B 70
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 58 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5h9o
Structure name
complex of murine endoplasmic reticulum alpha-glucosidase ii with d- glucose
Structure deposition date
2015-12-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O08795
Residue number A
58
Residue number B
70
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 58 of Glucosidase 2 subunit beta
Cysteine 70 of Glucosidase 2 subunit beta
5h9o D 56 D 58
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 56 and 58. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5h9o
Structure name
complex of murine endoplasmic reticulum alpha-glucosidase ii with d- glucose
Structure deposition date
2015-12-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
O08795
Residue number A
56
Residue number B
58
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 56 of Glucosidase 2 subunit beta
Cysteine 58 of Glucosidase 2 subunit beta
8d43 B 99 B 112
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 99 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14314
Residue number A
99
Residue number B
112
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 99 of Glucosidase 2 subunit beta
Cysteine 112 of Glucosidase 2 subunit beta
7jty D 99 D 100
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 99 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7jty
Structure name
co-crystal structure of alpha glucosidase with compound 1
Structure deposition date
2020-08-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
O08795
Residue number A
99
Residue number B
100
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 99 of Glucosidase 2 subunit beta
Cysteine 100 of Glucosidase 2 subunit beta
8d43 B 39 B 56
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 39 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
7
% buried
40
Peptide accession
P14314
Residue number A
39
Residue number B
56
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 39 of Glucosidase 2 subunit beta
Cysteine 56 of Glucosidase 2 subunit beta
7kb6 D 77 D 100
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 77 and 100. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7kb6
Structure name
co-crystal structure of alpha glucosidase with compound 7
Structure deposition date
2020-10-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
O08795
Residue number A
77
Residue number B
100
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 77 of Glucosidase 2 subunit beta
Cysteine 100 of Glucosidase 2 subunit beta
8d43 B 39 B 70
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 39 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
46
Peptide accession
P14314
Residue number A
39
Residue number B
70
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 39 of Glucosidase 2 subunit beta
Cysteine 70 of Glucosidase 2 subunit beta
8d43 B 97 B 99
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 97 and 99. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14314
Residue number A
97
Residue number B
99
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 97 of Glucosidase 2 subunit beta
Cysteine 99 of Glucosidase 2 subunit beta
8d43 B 77 B 112
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 77 and 112. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14314
Residue number A
77
Residue number B
112
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 77 of Glucosidase 2 subunit beta
Cysteine 112 of Glucosidase 2 subunit beta
8d43 B 99 B 116
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 99 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
10
% buried
nan
Peptide accession
P14314
Residue number A
99
Residue number B
116
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 99 of Glucosidase 2 subunit beta
Cysteine 116 of Glucosidase 2 subunit beta
8d43 B 77 B 116
A redox-regulated disulphide may form within Glucosidase 2 subunit beta between cysteines 77 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
8d43
Structure name
cryo-em structure of human kidney glucosidase ii
Structure deposition date
2022-06-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
nan
Peptide accession
P14314
Residue number A
77
Residue number B
116
Peptide name
Glucosidase 2 subunit beta
Ligandability
Cysteine 77 of Glucosidase 2 subunit beta
Cysteine 116 of Glucosidase 2 subunit beta
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