ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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D(2) dopamine receptor

Intramolecular
Cysteine 399 and cysteine 401
Cysteine 107 and cysteine 182
A redox-regulated disulphide may form within D(2) dopamine receptor between cysteines 399 and 401.

Details

Redox score ?
83
PDB code
7dfp
Structure name
human dopamine d2 receptor in complex with spiperone
Structure deposition date
2020-11-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14416
Residue number A
399
Residue number B
401
Peptide name
D(2) dopamine receptor

Ligandability

Cysteine 399 of D(2) dopamine receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 401 of D(2) dopamine receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within D(2) dopamine receptor between cysteines 107 and 182.

Details

Redox score ?
83
PDB code
6luq
Structure name
haloperidol bound d2 dopamine receptor structure inspired discovery of subtype selective ligands
Structure deposition date
2020-01-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P14416
Residue number A
107
Residue number B
182
Peptide name
D(2) dopamine receptor

Ligandability

Cysteine 107 of D(2) dopamine receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of D(2) dopamine receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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