ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Solute carrier family 2, facilitated glucose transporter member 4

Intramolecular
Cysteine 361 and cysteine 363
A redox-regulated disulphide may form within Solute carrier family 2, facilitated glucose transporter member 4 between cysteines 361 and 363. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7wsn
Structure name
cryo-em structure of human glucose transporter glut4 bound to cytochalasin b in detergent micelles
Structure deposition date
2022-01-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
42
Peptide accession
P14672
Residue number A
361
Residue number B
363
Peptide name
Solute carrier family 2, facilitated glucose transporter member 4

Ligandability

Cysteine 361 of Solute carrier family 2, facilitated glucose transporter member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 363 of Solute carrier family 2, facilitated glucose transporter member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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