ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Small nuclear ribonucleoprotein-associated proteins B and B'

Intramolecular
Cysteine 19 and cysteine 45
Cysteine 43 and cysteine 45
A redox-regulated disulphide may form within Small nuclear ribonucleoprotein-associated proteins B and B' between cysteines 19 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1d3b
Structure name
crystal structure of the d3b subcomplex of the human core snrnp domain at 2
Structure deposition date
1998-12-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
95
Peptide accession
P14678
Residue number A
19
Residue number B
45
Peptide name
Small nuclear ribonucleoprotein-associated proteins B and B'

Ligandability

Cysteine 19 of Small nuclear ribonucleoprotein-associated proteins B and B'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Small nuclear ribonucleoprotein-associated proteins B and B'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Small nuclear ribonucleoprotein-associated proteins B and B' between cysteines 43 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1d3b
Structure name
crystal structure of the d3b subcomplex of the human core snrnp domain at 2
Structure deposition date
1998-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
58
Peptide accession
P14678
Residue number A
43
Residue number B
45
Peptide name
Small nuclear ribonucleoprotein-associated proteins B and B'

Ligandability

Cysteine 43 of Small nuclear ribonucleoprotein-associated proteins B and B'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Small nuclear ribonucleoprotein-associated proteins B and B'

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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